TNF-α inhibitors for type 1 diabetes: exploring the path to a pivotal clinical trial.

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第一作者： Cassandra,Bazile

第一单位： Breakthrough T1D (formerly known as JDRF), New York, NY, United States.

作者： Cassandra,Bazile ^[1] ; Magdy M,Abdel Malik ^[2] ; Courtney,Ackeifi ^[1] ; Randy L,Anderson ^[3] ; Roy W,Beck ^[4] ; Marc Y,Donath ^[5] ; Sanjoy,Dutta ^[1] ; Joseph A,Hedrick ^[6] ; Stephen R,Karpen ^[1] ; Thomas W H,Kay ^[7] ; Thomas,Marder ^[8] ; Marjana,Marinac ^[1] ; Jennifer,McVean ^[9] ; Robert,Meyer ^[10] ; Jeremy,Pettus ^[11] ; Teresa,Quattrin ^[12] ; Ruud H J,Verstegen ^[13] ; Joshua A,Vieth ^[1] ; Esther,Latres ^[1]

作者单位： Breakthrough T1D (formerly known as JDRF), New York, NY, United States. ^[1] Quaestio Global Partners, LLC, Chester, NJ, United States. ^[2] Diabetes Clinical Development, Wilmington, NC, United States. ^[3] Jaeb Center for Health Research, Tampa, FL, United States. ^[4] Clinic of Endocrinology, Diabetes and Metabolism, University of Basel, Basel, Switzerland. ^[5] Critical Path Institute, Tucson, AZ, United States. ^[6] St Vincent's Institute of Medical Research, Fitzroy, VIC, Australia. ^[7] Putnam Associates, New York, NY, United States. ^[8] Medtronic, Northridge, CA, United States. ^[9] Greenleaf Health, Washington, DC, United States. ^[10] Division of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, CA, United States. ^[11] Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, United States. ^[12] Division of Clinical Pharmacology and Toxicology, Department of Pediatrics, Hospital for Sick Children, Toronto, ON, Canada.;Division of Rheumatology, Department of Pediatrics, Hospital for Sick Children, Toronto, ON, Canada. ^[13]

关键词 T1D TNF-α autoimmunity clinical trial disease modifying therapies

主题词人类(Humans);糖尿病, 1型(Diabetes Mellitus, Type 1);肿瘤坏死因子α(Tumor Necrosis Factor-alpha);临床试验(主题)(Clinical Trials as Topic);胰岛素分泌细胞(Insulin-Secreting Cells);降血糖药(Hypoglycemic Agents);动物(Animals)

DOI 10.3389/fimmu.2024.1470677

PMID 39411715

发布时间 2024-10-18

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