Rational design of pH-responsive nano-delivery system with improved biocompatibility and targeting ability from cellulose nanocrystals via surface polymerization for intracellular drug delivery.

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作者： Ziqi,Li ^[1] ; Xi,Wang ^[2] ; Weimin,Wan ^[2] ; Na,Zhang ^[2] ; Limeng,Zhang ^[2] ; Xiaoye,Wang ^[3] ; Kui,Lin ^[4] ; Jian,Yang ^[2] ; Jia,Hao ^[2] ; Fei,Tian ^[5]

作者单位： National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, PR China; Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, PR China; Department of Pharmacy, Jiangxi Maternal and Child Health Hospital, Jiangxi 330103, PR China. ^[1] National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, PR China; Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, PR China. ^[2] Department of Critical Care Medicine, Tianjin Medical University General Hospital, Tianjin 300052, China. ^[3] Analytical Instrumentation Centre, Tianjin University, Tianjin 300072, PR China. ^[4] National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, PR China; Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, PR China. Electronic address: tianfei.louise@163.com. ^[5]

关键词 Active targeting delivery Cellulose nanocrystals Hyperbranched polymer SET-LRP pH-responsive