首页> Acta pharmacologica Sinica> A recombinant fragment antigen-binding (Fab) of trastuzumab displays low cytotoxic profile in adult human cardiomyocytes: first evidence and the key implication of FcγRIIA receptor.

A recombinant fragment antigen-binding (Fab) of trastuzumab displays low cytotoxic profile in adult human cardiomyocytes: first evidence and the key implication of FcγRIIA receptor.

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第一作者： Anna,De Bartolo

第一单位： Department of Biology, E. and E. S. (DiBEST), Cellular and Molecular Cardiovascular Physiology and Pathophysiology Laboratory, University of Calabria, Cosenza, Italy.

作者： Anna,De Bartolo ^[1] ; Naomi,Romeo ^[1] ; Alessandro,Marrone ^[1] ; Vittoria,Rago ^[2] ; Maria Concetta,Granieri ^[1] ; Maria Luigia,Vommaro ^[3] ; Arianna,Cupelli ^[4] ; Maria Carmela,Cerra ^[4] ; Cesare,Indiveri ^[5] ; Raffaele,Ronca ^[6] ; Maria,Cantile ^[6] ; Riccardo,Sanna ^[6] ; Carmine,Rocca ^[7] ; Tommaso,Angelone ^[8]

作者单位： Department of Biology, E. and E. S. (DiBEST), Cellular and Molecular Cardiovascular Physiology and Pathophysiology Laboratory, University of Calabria, Cosenza, Italy. ^[1] Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Cosenza, Italy. ^[2] Department of Biology, E. and E. S. (DiBEST), University of Calabria, Rende, Italy. ^[3] Department of Biology, E. and E. S. (DiBEST), Organ and System Physiology Laboratory, University of Calabria, Cosenza, Italy. ^[4] Department of Biology, E. and E. S. (DiBEST), Unit of Biochemistry, Molecular Biotechnology, and Molecular Biology, University of Calabria, Cosenza, Italy.;CNR Institute of Biomembranes, Bioenergetics and Molecular Biotechnology, Bari, Italy. ^[5] BIOVIIIX, Napoli, Italy. ^[6] Department of Biology, E. and E. S. (DiBEST), Cellular and Molecular Cardiovascular Physiology and Pathophysiology Laboratory, University of Calabria, Cosenza, Italy. carmine.rocca@unical.it.;National Institute of Cardiovascular Research (INRC), Bologna, Italy. carmine.rocca@unical.it. ^[7] Department of Biology, E. and E. S. (DiBEST), Cellular and Molecular Cardiovascular Physiology and Pathophysiology Laboratory, University of Calabria, Cosenza, Italy. tommaso.angelone@unical.it.;National Institute of Cardiovascular Research (INRC), Bologna, Italy. tommaso.angelone@unical.it. ^[8]

关键词 Fc region FcγRIIA HER2 cardiac complications rFab-HER2 trastuzumab

医学主题词人类(Humans);肌细胞, 心脏(Myocytes, Cardiac);受体, IgG(Receptors, IgG);免疫球蛋白Fab片段(Immunoglobulin Fab Fragments);重组蛋白质类(Recombinant Proteins);细胞凋亡(Apoptosis);细胞系(Cell Line)

DOI 10.1038/s41401-024-01397-3

PMID 39414958

发布时间 2025-07-08

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