Development of new K<sub>ir</sub>2.1 channel openers from propafenone analogues.

导出 LinkOut

翻译打印收藏纠错

第一作者： Encan,Li

第一单位： Department of Medical Physiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.

作者： Encan,Li ^[1] ; Najla,Boujeddaine ^[1] ; Marien J C,Houtman ^[1] ; Renee G C,Maas ^[2] ; Joost P G,Sluijter ^[2] ; Gerhard F,Ecker ^[3] ; Anna,Stary-Weinzinger ^[3] ; Willem B,van Ham ^[1] ; Marcel A G,van der Heyden ^[1]

作者单位： Department of Medical Physiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands. ^[1] Department of Cardiology, Laboratory of Experimental Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.;Circulatory Health Research Center, Regenerative Medicine Center Utrecht, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands. ^[2] Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria. ^[3]

关键词 Kir2.1 channel cardiac pharmacology drug discovery/target validation hiPSC‐CMCs ion channels off‐target effects propafenone analogues

主题词钾通道, 内向整流(Potassium Channels, Inwardly Rectifying);普罗帕酮(Propafenone);人类(Humans);肌细胞, 心脏(Myocytes, Cardiac);诱导多能干细胞(Induced Pluripotent Stem Cells);HEK293细胞(HEK293 Cells);动作电位(Action Potentials)

DOI 10.1111/bph.17377

PMID 39419581

发布时间 2025-01-02

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交