Evaluation of PLGA, lipid-PLGA hybrid nanoparticles, and cationic pH-sensitive liposomes as tuberculosis vaccine delivery systems in a Mycobacterium tuberculosis challenge mouse model - A comparison.

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第一作者： Mikołaj M,Szachniewicz

第一单位： Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center (LUMC), the Netherlands. Electronic address: m.m.szachniewicz@lumc.nl.

作者： Mikołaj M,Szachniewicz ^[1] ; Malene A,Neustrup ^[2] ; Susan J F,van den Eeden ^[3] ; Krista E,van Meijgaarden ^[3] ; Kees L M C,Franken ^[3] ; Suzanne,van Veen ^[3] ; Roman I,Koning ^[4] ; Ronald W A L,Limpens ^[4] ; Annemieke,Geluk ^[3] ; Joke A,Bouwstra ^[2] ; Tom H M,Ottenhoff ^[3]

作者单位： Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center (LUMC), the Netherlands. Electronic address: m.m.szachniewicz@lumc.nl. ^[1] Division of BioTherapeutics, Leiden Academic Centre for Drug Research (LACDR), Leiden University, the Netherlands. ^[2] Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center (LUMC), the Netherlands. ^[3] Electron Microscopy Facility, Leiden University Medical Center (LUMC), the Netherlands. ^[4]

关键词 Adjuvant Cationic lipid?PLGA hybrid nanoparticles Cationic pH-sensitive liposome PLGA nanoparticles Subunit vaccine Tuberculosis