COL25A1 and METAP1D DNA methylation are promising liquid biopsy epigenetic biomarkers of colorectal cancer using digital PCR.

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作者： Alexis,Overs ^[1] ; Paul,Peixoto ^[2] ; Eric,Hervouet ^[2] ; Chloé,Molimard ^[3] ; Franck,Monnien ^[3] ; Jules,Durand ^[2] ; Michael,Guittaut ^[2] ; Angélique,Vienot ^[4] ; Julien,Viot ^[4] ; Michael,Herfs ^[5] ; Christophe,Borg ^[6] ; Jean-Paul,Feugeas ^[7] ; Zohair,Selmani ^[7]

作者单位： Department of Oncobiology, University Hospital of Besançon, 3 Boulevard Alexandre Fleming, 25000, Besançon, France. aovers@chu-besancon.fr.;UMR1098, INSERM, University of Bourgogne Franche-Comté, Besançon, France. aovers@chu-besancon.fr. ^[1] UMR1098, INSERM, University of Bourgogne Franche-Comté, Besançon, France. ^[2] Department of Pathology, University Hospital of Besançon, 25000, Besancon, France. ^[3] Department of Oncology, University Hospital of Besançon, 25000, Besancon, France. ^[4] Laboratory of Experimental Pathology, GIGA-Cancer, University of Liege, Liège, Belgium. ^[5] UMR1098, INSERM, University of Bourgogne Franche-Comté, Besançon, France.;Department of Oncology, University Hospital of Besançon, 25000, Besancon, France. ^[6] Department of Oncobiology, University Hospital of Besançon, 3 Boulevard Alexandre Fleming, 25000, Besançon, France.;UMR1098, INSERM, University of Bourgogne Franche-Comté, Besançon, France. ^[7]

关键词 Biomarker COL25A1 Circulating tumor DNA Colorectal cancer DNA methylation Digital PCR Liquid biopsy METAP1D