Obicetrapib exhibits favorable physiochemical and pharmacokinetic properties compared to previous cholesteryl ester transfer protein inhibitors: An integrated summary of results from non-human primate studies and clinical trials.

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第一作者： Stephen J,Nicholls

第一单位： Victorian Heart Institute, Monash University, Melbourne, Victoria, Australia.

作者： Stephen J,Nicholls ^[1] ; Adam J,Nelson ^[1] ; John J P,Kastelein ^[2] ; Marc,Ditmarsch ^[2] ; Andrew,Hsieh ^[2] ; Judith,Johnson ^[2] ; Danielle,Curcio ^[2] ; Douglas,Kling ^[2] ; Carol F,Kirkpatrick ^[3] ; Michael H,Davidson ^[2]

作者单位： Victorian Heart Institute, Monash University, Melbourne, Victoria, Australia. ^[1] NewAmsterdam Pharma B.V, Naarden, The Netherlands. ^[2] Midwest Biomedical Research, Addison, Illinois, USA. ^[3]

关键词 accumulation anacetrapib cholesteryl ester transfer protein elimination obicetrapib pharmacokinetics toxicokinetic

主题词胆固醇酯转运蛋白质类(Cholesterol Ester Transfer Proteins);动物(Animals);人类(Humans);恶唑烷酮类(Oxazolidinones);成束猴(Macaca fascicularis);抗胆固醇血症药(Anticholesteremic Agents);半衰期(Half-Life);酯类(Esters);食品药物相互作用(Food-Drug Interactions)

DOI 10.1002/prp2.70010

PMID 39425271

发布时间 2024-11-10

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Pharmacology research & perspectives

2024年12卷6期

e70010页

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Obicetrapib exhibits favorable physiochemical and pharmacokinetic properties compared to previous cholesteryl ester transfer protein inhibitors: An integrated summary of results from non-human primate studies and clinical trials.

Pharmacology research & perspectives

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Pharmacology research & perspectives

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Obicetrapib exhibits favorable physiochemical and pharmacokinetic properties compared to previous cholesteryl ester transfer protein inhibitors: An integrated summary of results from non-human primate studies and clinical trials.

Pharmacology research & perspectives

相似文献

Pharmacology research & perspectives

相关期刊

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