Mitochondrial pyruvate carriers control airway basal progenitor cell function through glycolytic-epigenetic reprogramming.

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第一作者： Yawen,Li

第一单位： Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.

作者： Yawen,Li ^[1] ; Yalin,He ^[1] ; Qi,Zheng ^[2] ; Jiazhu,Zhang ^[1] ; Xinwen,Pan ^[1] ; Xi,Zhang ^[1] ; Huairui,Yuan ^[1] ; Guangchuan,Wang ^[1] ; Xin,Liu ^[1] ; Xiaolong,Zhou ^[3] ; Xueliang,Zhu ^[1] ; Tao,Ren ^[4] ; Pengfei,Sui ^[5]

作者单位： Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China. ^[1] Department of Respiratory and Clinical Care Medicine, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China. ^[2] Key Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China. ^[3] Department of Respiratory and Clinical Care Medicine, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China. Electronic address: rentao305@163.com. ^[4] Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China. Electronic address: pfsui@sibcb.ac.cn. ^[5]

关键词 airway cell fate decision injury repair lung basal progenitor cell lung epithelium homeostasis lung progenitor cell metabolism mitochondrial pyruvate carrier