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Population pharmacokinetic analysis of sirolimus in Japanese pediatric and adult subjects receiving tablet or granule formulations.

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第一作者： Taichi,Miyazaki

第一单位： Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu, Japan.

作者： Taichi,Miyazaki ^[1] ; Daichi,Hayashi ^[1] ; Akifumi,Nozawa ^[1] ; Shiho,Yasue ^[1] ; Saori,Endo ^[1] ; Hidenori,Ohnishi ^[1] ; Ryuta,Asada ^[2] ; Mototoshi,Kato ^[3] ; Akihiro,Fujino ^[3] ; Tatsuo,Kuroda ^[3] ; Takanobu,Maekawa ^[4] ; Shigehisa,Fumino ^[5] ; Naonori,Kawakubo ^[6] ; Tatsuro,Tajiri ^[6] ; Kenji,Shimizu ^[7] ; Chihiro,Sanada ^[7] ; Izumi,Hamada ^[8] ; Yuko,Ishikawa ^[8] ; Mayumi,Hasegawa ^[9] ; Kashyap,Patel ^[9] ; Yehua,Xie ^[9] ; Michio,Ozeki ^[10]

作者单位： Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu, Japan. ^[1] Innovative and Clinical Research Promotion Center, Gifu University Hospital, Gifu, Japan. ^[2] Department of Pediatric Surgery, Keio University School of Medicine, Tokyo, Japan. ^[3] Department of General Pediatrics and Interdisciplinary Medicine, National Center for Child Health and Development, Tokyo, Japan. ^[4] Department of Pediatric Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan. ^[5] Department of Pediatric Surgery, Reproductive and Developmental Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan. ^[6] Department of Clinical Development, Nobelpharma, Co., Ltd, Tokyo, Japan. ^[7] Department of Data Science, Nobelpharma, Co., Ltd, Tokyo, Japan. ^[8] Certara Inc, USA. ^[9] Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu, Japan. Electronic address: ozeki.michio.j5@f.gifu-u.ac.jp. ^[10]

关键词 Population pharmacokinetic analysis Therapeutic drug monitoring Vascular anomalies