Thermal and pH stress dictate distinct mechanisms of monoclonal antibody aggregation.

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第一作者： Hoi Kong,Meng

第一单位： Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.

作者： Hoi Kong,Meng ^[1] ; Kuin Tian,Pang ^[2] ; Corrine,Wan ^[1] ; Zi Ying,Zheng ^[1] ; Qiu,Beiying ^[1] ; Yuansheng,Yang ^[1] ; Wei,Zhang ^[1] ; Ying Swan,Ho ^[1] ; Ian,Walsh ^[3] ; Sean,Chia ^[4]

作者单位： Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. ^[1] Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore; Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore; Department of Biomedical Engineering, National University of Singapore, Singapore; School of Chemistry, Chemical Engineering, and Biotechnology, Nanyang Technology University, Singapore. ^[2] Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. Electronic address: ian_walsh@bti.a-star.edu.sg. ^[3] Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. Electronic address: sean_chia@bti.a-star.edu.sg. ^[4]

关键词 Antibodies Chemical kinetics Developability Protein aggregation

主题词氢离子浓度(Hydrogen-Ion Concentration);抗体, 单克隆(Antibodies, Monoclonal);温度(Temperature);动力学(Kinetics);蛋白质稳定性(Protein Stability);动物(Animals)

DOI 10.1016/j.ijbiomac.2024.136601

PMID 39427803

发布时间 2024-12-03

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准确一般字义偏差语意偏离译文作用小提交