Discovery and Synthesis of Heterobifunctional Degraders of Rearranged during Transfection (RET) Kinase.

导出 LinkOut

翻译打印收藏纠错

作者： Jennifer X,Qiao ^[1] ; David,Williams ^[1] ; Patrice,Gill ^[1] ; Ling,Li ^[1] ; Derek,Norris ^[1] ; John S,Tokarski ^[2] ; Jessica,Wong ^[3] ; Huilin,Qi ^[3] ; Yamnah,Hafeji ^[3] ; Daniel P,Downes ^[4] ; Bill,Degnen ^[4] ; Ying-Kai,Wang ^[4] ; Gregory,Locke ^[4] ; Hua,Fang ^[4] ; Fei,Yu ^[4] ; Songmei,Xu ^[4] ; Joseph,Naglich ^[4] ; Jun,Zhang ^[4] ; Purushothama,Nanjappa ^[5] ; Chao,Dai ^[5] ; Lisa,Chourb ^[6] ; Jonathan,Napoline ^[6] ; Richland,Tester ^[7] ; Christine,Jorge ^[7] ; Yi-Xin,Li ^[7] ; Arvind,Mathur ^[7] ; Christopher,Barbieri ^[4] ; Matthew G,Soars ^[6] ; Avinashnarayan,Venkatanarayan ^[3] ; Emma,Lees ^[3] ; Robert M,Borzilleri ^[1] ; Ashvinikumar V,Gavai ^[1] ; Michael,Wichroski ^[3] ; T G Murali,Dhar ^[1]

作者单位： Discovery Chemistry, Bristol Myers Squibb, Princeton, New Jersey 08540, United States. ^[1] Molecular Structure & Design, Bristol Myers Squibb, Princeton, New Jersey 08540, United States. ^[2] Oncology Discovery Biology, Mechanism of Cancer Resistance, Bristol Myers Squibb, Cambridge, Massachusetts 02141, United States. ^[3] Leads Discovery & Optimization, Bristol Myers Squibb, Princeton, New Jersey 08540, United States. ^[4] Discovery Pharmacology and in vivo Biology, Bristol Myers Squibb, Cambridge, Massachusetts 02141, United States. ^[5] Pharmaceutical Candidate Optimization, Bristol Myers Squibb, Cambridge, Massachusetts 02141, United States. ^[6] Department of Discovery Synthesis, Bristol Myers Squibb, Princeton, New Jersey 08540, United States. ^[7]