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Annonaceous acetogenins mimic AA005 targets mitochondrial trifunctional enzyme alpha subunit to treat obesity in male mice.

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作者单位: Center for Traditional Chinese Medicine and Gut Microbiota, Minhang Hospital, Fudan University, Shanghai, China.;Institute of Fudan-Minhang Academic Health System, Minhang Hospital, Fudan University, Shanghai, China. [1] Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China. [2] School of Life Science, Peking University, Beijing, China. [3] The Department of Geriatrics, RenJi Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China. [4] State Key Laboratory of Genetic Engineering, Department of Biochemistry and Biophysics, School of Life Sciences, Fudan University, Shanghai, China. [5] State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China. yaoz@nju.edu.cn. [6] School of Basic Medicine and Life Science, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, China. chengq@shsmu.edu.cn.;Institute of Aging & Tissue Regeneration, State Key Laboratory of Systems Medicine for Cancer, and Chinese Academy of Medical Sciences Research Unit (NO.2019RU043), Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. chengq@shsmu.edu.cn. [7] Center for Traditional Chinese Medicine and Gut Microbiota, Minhang Hospital, Fudan University, Shanghai, China. lishunwang@fudan.edu.cn.;Institute of Fudan-Minhang Academic Health System, Minhang Hospital, Fudan University, Shanghai, China. lishunwang@fudan.edu.cn. [8]
DOI 10.1038/s41467-024-53118-3
PMID 39438446
发布时间 2024-10-25
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