Generation of human expandable limb-bud-like progenitors via chemically induced dedifferentiation.

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第一作者： Jialiang,Zhu

第一单位： MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences and MOE Engineering Research Center of Regenerative Medicine, School of Basic Medical Sciences, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China; BeiCell Therapeutics, Beijing, China; BeiCell Therapeutics, Suzhou, China.

作者： Jialiang,Zhu ^[1] ; Xinxing,Zhong ^[2] ; Huanjing,He ^[3] ; Jingxiao,Cao ^[4] ; Zhengyang,Zhou ^[3] ; Jiebin,Dong ^[3] ; Honggang,Li ^[3] ; Anqi,Zhang ^[3] ; Yulin,Lyu ^[5] ; Cheng,Li ^[5] ; Jingyang,Guan ^[6] ; Hongkui,Deng ^[7]

作者单位： MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences and MOE Engineering Research Center of Regenerative Medicine, School of Basic Medical Sciences, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China; BeiCell Therapeutics, Beijing, China; BeiCell Therapeutics, Suzhou, China. ^[1] MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences and MOE Engineering Research Center of Regenerative Medicine, School of Basic Medical Sciences, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China; State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, China. ^[2] MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences and MOE Engineering Research Center of Regenerative Medicine, School of Basic Medical Sciences, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China. ^[3] MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences and MOE Engineering Research Center of Regenerative Medicine, School of Basic Medical Sciences, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China; School of Life Sciences, Center for Bioinformatics, Center for Statistical Science, Peking University, Beijing, China. ^[4] School of Life Sciences, Center for Bioinformatics, Center for Statistical Science, Peking University, Beijing, China. ^[5] State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Ningbo Institute of Marine Medicine, Peking University, Beijing, China. Electronic address: guanjingyang@hsc.pku.edu.cn. ^[6] MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences and MOE Engineering Research Center of Regenerative Medicine, School of Basic Medical Sciences, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China; State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, China; Changping Laboratory, Beijing, China. Electronic address: hongkui_deng@pku.edu.cn. ^[7]

关键词 chemical reprogramming dedifferentiation human limb-bud-like progenitors large-scale expansion progenitor maintenance regeneration

主题词人类(Humans);细胞去分化(Cell Dedifferentiation);肢芽(Limb Buds);细胞分化(Cell Differentiation);干细胞(Stem Cells);细胞, 培养的(Cells, Cultured);细胞增殖(Cell Proliferation)

DOI 10.1016/j.stem.2024.10.001

PMID 39442525

发布时间 2024-12-06

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