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USP10 drives cancer stemness and enables super-competitor signalling in colorectal cancer.

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作者单位: Protein Stability and Cancer Group, University of Wuerzburg, Department of Biochemistry and Molecular Biology, Wuerzburg, Germany.;Mildred-Scheel Early Career Cancer Center, Wuerzburg, Germany.;Max Planck Institute for Molecular Genetics, Berlin, Germany. [1] Protein Stability and Cancer Group, University of Wuerzburg, Department of Biochemistry and Molecular Biology, Wuerzburg, Germany.;Mildred-Scheel Early Career Cancer Center, Wuerzburg, Germany. [2] Protein Stability and Cancer Group, University of Wuerzburg, Department of Biochemistry and Molecular Biology, Wuerzburg, Germany.;Division of Signal Transduction and Growth Control, DKFZ/ZMBH Alliance, German Cancer Research Center (DKFZ), Heidelberg, Germany. [3] Oncode Institute and Department of Cell Biology, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, Netherlands. [4] Protein Stability and Cancer Group, University of Wuerzburg, Department of Biochemistry and Molecular Biology, Wuerzburg, Germany.;Molecular Signalling Group, Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt am Main, Germany. [5] Rudolf-Virchow-Center for Integrative and Translational Imaging, University of Wuerzburg, Wuerzburg, Germany. [6] Mildred-Scheel Early Career Cancer Center, Wuerzburg, Germany.;Department of Biochemistry and Molecular Biology, University of Wuerzburg, Wuerzburg, Germany. [7] Department of Biochemistry and Molecular Biology, University of Wuerzburg, Wuerzburg, Germany. [8] Faculty of Medicine, TICC, Technion Haifa, Haifa, Israel. [9] Cancer Systems Biology Group, University of Wuerzburg, Am Hubland, Wuerzburg, Germany. [10] Molecular Signalling Group, Institute of Biochemistry II, Goethe University Frankfurt, Frankfurt am Main, Germany. [11] Protein Stability and Cancer Group, University of Wuerzburg, Department of Biochemistry and Molecular Biology, Wuerzburg, Germany.;Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital, University of Wuerzburg, Wuerzburg, Germany. [12] Institute for Pathology, University of Würzburg, Wuerzburg, Germany. [13] Angiogenesis & Metabolism Laboratory, Berlin Institute of Health at Charité, Universitätsmedizin Berlin, Berlin Germany and Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany. [14] Stem Cell and Cancer Biology Laboratory, The Francis Crick Institute, London, UK. [15] Department of Biochemistry and Molecular Biology, University of Wuerzburg, Wuerzburg, Germany.;Department of General, Visceral, Transplantation, Vascular and Paediatric Surgery, University Hospital, Julius-Maximilians-University of Wuerzburg, Wuerzburg, Germany. [16] Amsterdam Institute of Molecular and Life Sciences, Amsterdam, Netherlands. [17] Mildred-Scheel Early Career Cancer Center, Wuerzburg, Germany.;Cancer Systems Biology Group, University of Wuerzburg, Am Hubland, Wuerzburg, Germany. [18] Mildred-Scheel Early Career Cancer Center, Wuerzburg, Germany.;Institute for Pathology, University of Würzburg, Wuerzburg, Germany. [19] Protein Stability and Cancer Group, University of Wuerzburg, Department of Biochemistry and Molecular Biology, Wuerzburg, Germany. markus.diefenbacher@helmholtz-munich.de.;Mildred-Scheel Early Career Cancer Center, Wuerzburg, Germany. markus.diefenbacher@helmholtz-munich.de.;Institute of Lung Health and Immunity, Helmholtz Center, Munich, Germany. markus.diefenbacher@helmholtz-munich.de.;German Center for Lung Research, DZL, Germany. markus.diefenbacher@helmholtz-munich.de.;Ludwig Maximilian University Munich, Munich, Germany. markus.diefenbacher@helmholtz-munich.de. [20]
DOI 10.1038/s41388-024-03141-x
PMID 39443725
发布时间 2025-02-05
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