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KRAS-mediated upregulation of CIP2A promotes suppression of PP2A-B56α to initiate pancreatic cancer development.

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第一作者： Samantha L,Tinsley

第一单位： Purdue University Interdisciplinary Life Sciences Program (PULSe), Purdue University, West Lafayette, IN, USA.;Department of Biological Sciences, Purdue University, West Lafayette, IN, USA.

作者： Samantha L,Tinsley ^[1] ; Ella Rose D,Chianis ^[2] ; Rebecca A,Shelley ^[2] ; Gaganpreet K,Mall ^[2] ; Alisha,Dhiman ^[3] ; Garima,Baral ^[2] ; Harish,Kothandaraman ^[4] ; Mary C,Thoma ^[5] ; Isabel A,English ^[5] ; Colin J,Daniel ^[5] ; Luis Carlos Sanjuan,Acosta ^[6] ; Luis,Solorio ^[7] ; Nadia,Atallah Lanman ^[8] ; Marina,Pasca di Magliano ^[9] ; Goutham,Narla ^[9] ; Emily C,Dykhuizen ^[10] ; Rosalie C,Sears ^[11] ; Brittany L,Allen-Petersen ^[12]

作者单位： Purdue University Interdisciplinary Life Sciences Program (PULSe), Purdue University, West Lafayette, IN, USA.;Department of Biological Sciences, Purdue University, West Lafayette, IN, USA. ^[1] Department of Biological Sciences, Purdue University, West Lafayette, IN, USA. ^[2] Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA. ^[3] Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN, USA. ^[4] Department of Molecular Medicine and Genetics, Oregon Health and Sciences University, Portland, OR, USA. ^[5] Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA. ^[6] Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN, USA.;Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA. ^[7] Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN, USA.;Department of Comparative Pathobiology, Purdue University, West Lafayette, IN, USA. ^[8] Department of Internal Medicine, Rogel Cancer Center, The University of Michigan, Ann Arbor, MI, USA. ^[9] Purdue University Interdisciplinary Life Sciences Program (PULSe), Purdue University, West Lafayette, IN, USA.;Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA.;Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN, USA. ^[10] Department of Molecular Medicine and Genetics, Oregon Health and Sciences University, Portland, OR, USA.;Brenden-Colson Center for Pancreatic Care, Oregon Health and Sciences University, Portland, OR, USA. ^[11] Purdue University Interdisciplinary Life Sciences Program (PULSe), Purdue University, West Lafayette, IN, USA. ballenpe@purdue.edu.;Department of Biological Sciences, Purdue University, West Lafayette, IN, USA. ballenpe@purdue.edu.;Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN, USA. ballenpe@purdue.edu. ^[12]