Differential stiffness between brain vasculature and parenchyma promotes metastatic infiltration through vessel co-option.

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作者： Marina,Uroz ^[1] ; Amy E,Stoddard ^[2] ; Bryan P,Sutherland ^[1] ; Olivia,Courbot ^[3] ; Roger,Oria ^[4] ; Linqing,Li ^[5] ; Cara R,Ravasio ^[6] ; Mai T,Ngo ^[1] ; Jinling,Yang ^[1] ; Juliann B,Tefft ^[1] ; Jeroen,Eyckmans ^[1] ; Xue,Han ^[6] ; Alberto,Elosegui-Artola ^[3] ; Valerie M,Weaver ^[7] ; Christopher S,Chen ^[8]

作者单位： Department of Biomedical Engineering, Boston University, Boston, MA, USA.;The Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.;Biological Design Center, Boston University, Boston, MA, USA. ^[1] Department of Biomedical Engineering, Boston University, Boston, MA, USA.;The Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.;Biological Design Center, Boston University, Boston, MA, USA.;Harvard-MIT Program in Health Sciences and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA. ^[2] Cell and Tissue Mechanobiology Laboratory, The Francis Crick Institute, London, UK.;Department of Physics, King's College London, London, UK. ^[3] Department of Surgery, University of California, San Francisco, CA, USA.;Center for Bioengineering and Tissue Regeneration, University of California San Francisco, San Francisco, CA, USA. ^[4] Department of Biomedical Engineering, Boston University, Boston, MA, USA.;The Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.;Biological Design Center, Boston University, Boston, MA, USA.;Department of Chemical Engineering, University of New Hampshire, Durham, NH, USA. ^[5] Department of Biomedical Engineering, Boston University, Boston, MA, USA. ^[6] Department of Surgery, University of California, San Francisco, CA, USA.;Center for Bioengineering and Tissue Regeneration, University of California San Francisco, San Francisco, CA, USA.;UCSF Helen Diller Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.;Department of Radiation Oncology, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA. ^[7] Department of Biomedical Engineering, Boston University, Boston, MA, USA. chencs@bu.edu.;The Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA. chencs@bu.edu.;Biological Design Center, Boston University, Boston, MA, USA. chencs@bu.edu. ^[8]