Immunotherapy response induces divergent tertiary lymphoid structure morphologies in hepatocellular carcinoma.
作者:
Daniel H,Shu [1]
;
Won Jin,Ho [2]
;
Luciane T,Kagohara [2]
;
Alexander,Girgis [3]
;
Sarah M,Shin [4]
;
Ludmila,Danilova [4]
;
Jae W,Lee [5]
;
Dimitrios N,Sidiropoulos [2]
;
Sarah,Mitchell [4]
;
Kabeer,Munjal [4]
;
Kathryn,Howe [4]
;
Kayla J,Bendinelli [4]
;
Emma,Kartalia [4]
;
Hanfei,Qi [4]
;
Guanglan,Mo [4]
;
Janelle,Montagne [2]
;
James M,Leatherman [4]
;
Tamara Y,Lopez-Vidal [2]
;
Qingfeng,Zhu [6]
;
Amanda L,Huff [2]
;
Xuan,Yuan [7]
;
Alexei,Hernandez [4]
;
Erin M,Coyne [4]
;
Neeha,Zaidi [2]
;
Daniel J,Zabransky [2]
;
Logan L,Engle [8]
;
Aleksandra,Ogurtsova [8]
;
Marina,Baretti [4]
;
Daniel,Laheru [2]
;
Jennifer N,Durham [4]
;
Hao,Wang [4]
;
Joel C,Sunshine [9]
;
Robert J,Johnston [10]
;
Julie Stein,Deutsch [8]
;
Janis M,Taube [8]
;
Robert A,Anders [6]
;
Elizabeth M,Jaffee [11]
;
Elana J,Fertig [12]
;
Mark,Yarchoan [13]
作者单位:
Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD, USA.;Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA.;Convergence Institute, Johns Hopkins University, Baltimore, MD, USA.
[1]
Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA.;Convergence Institute, Johns Hopkins University, Baltimore, MD, USA.
[2]
Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA.;Convergence Institute, Johns Hopkins University, Baltimore, MD, USA.;Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
[3]
Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
[4]
Department of Pathology, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
[5]
Convergence Institute, Johns Hopkins University, Baltimore, MD, USA.;Department of Pathology, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
[6]
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
[7]
Department of Dermatology, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA.;The Mark Foundation Center for Advanced Genomics and Imaging, Johns Hopkins University, Baltimore, MD, USA.;Bloomberg∼Kimmel Institute for Cancer Immunotherapy and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA.
[8]
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA.;Department of Pathology, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA.;Department of Dermatology, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA.;The Mark Foundation Center for Advanced Genomics and Imaging, Johns Hopkins University, Baltimore, MD, USA.;Bloomberg∼Kimmel Institute for Cancer Immunotherapy and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA.
[9]
Genentech Inc, South San Francisco, CA, USA.
[10]
Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA.;Convergence Institute, Johns Hopkins University, Baltimore, MD, USA.;Bloomberg∼Kimmel Institute for Cancer Immunotherapy and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA.
[11]
Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA. ejfertig@jhmi.edu.;Convergence Institute, Johns Hopkins University, Baltimore, MD, USA. ejfertig@jhmi.edu.;Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA. ejfertig@jhmi.edu.;Department of Applied Mathematics and Statistics, Johns Hopkins University Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA. ejfertig@jhmi.edu.
[12]
Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA. mark.yarchoan@jhmi.edu.;Convergence Institute, Johns Hopkins University, Baltimore, MD, USA. mark.yarchoan@jhmi.edu.;Bloomberg∼Kimmel Institute for Cancer Immunotherapy and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA. mark.yarchoan@jhmi.edu.
[13]
主题词
癌, 肝细胞(Carcinoma, Hepatocellular);肝肿瘤(Liver Neoplasms);人类(Humans);免疫疗法(Immunotherapy);男(雄)性(Male);女(雌)性(Female);中年人(Middle Aged);预后(Prognosis);老年人(Aged);肿瘤辅助疗法(Neoadjuvant Therapy);淋巴细胞, 肿瘤浸润(Lymphocytes, Tumor-Infiltrating);免疫记忆(Immunologic Memory);树突细胞(Dendritic Cells)
DOI
10.1038/s41590-024-01992-w
PMID
39455893
发布时间
2025-01-04
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Nature immunology
Nature immunology
2110-2123页
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