Novel Dual Acetyl- and Butyrylcholinesterase Inhibitors Based on the Pyridyl-Pyridazine Moiety for the Potential Treatment of Alzheimer's Disease.

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作者： Mohamed,Elsawalhy ^[1] ; Adel A-H,Abdel-Rahman ^[1] ; Ebtesam A,Basiony ^[1] ; Salma A,Ellithy ^[1] ; Allam A,Hassan ^[2] ; Eman S,Abou-Amra ^[3] ; Abdelhamid,Ismail ^[1] ; Abdulrahman A,Almehizia ^[4] ; Mohamed A,Al-Omar ^[4] ; Ahmed M,Naglah ^[4] ; Nasser A,Hassan ^[5]

作者单位： Department of Chemistry, Faculty of Science, Menofia University, Shbien El-Kom 32511, Egypt. ^[1] Department of Chemistry, Faculty of Science, Suez University, Suez 43221, Egypt. ^[2] Department of Chemistry, Organic Chemistry, Faculty of Science (Girls), Al-Azhar University, Cairo 11754, Egypt. ^[3] Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia. ^[4] Synthetic Unit, Department of Photochemistry, Chemical Industries Research Institute, National Research Centre, Cairo 12622, Egypt. ^[5]

关键词 Alzheimer’s disease acetylcholinesterase butyrylcholinesterase click chemistry pyridazine spectroscopic techniques

DOI 10.3390/ph17101407

PMID 39459045

发布时间 2024-10-28

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