Bisdemethoxycurcumin, a novel potent polyphenolic compound, effectively inhibits the formation of amyloid aggregates in ALS-associated hSOD1 mutant (L38R).
作者:
主题词
二芳基庚烷类(Diarylheptanoids);人类(Humans);肌萎缩侧索硬化(Amyotrophic Lateral Sclerosis);淀粉样蛋白(Amyloid);突变(Mutation);分子动力学模拟(Molecular Dynamics Simulation);姜黄素(Curcumin);溶血(Hemolysis);亲水和疏水相互作用(Hydrophobic and Hydrophilic Interactions)
DOI
10.1016/j.ijbiomac.2024.136701
PMID
39461630
发布时间
2024-12-03
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