Identification of lipid senolytics targeting senescent cells through ferroptosis induction.

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第一作者： Lei Justan,Zhang

第一单位： Institute on the Biology of Aging and Metabolism and the Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.

作者： Lei Justan,Zhang ^[1] ; Rahagir,Salekeen ^[1] ; Carolina,Soto-Palma ^[1] ; Osama,Elsallabi ^[2] ; Hongping,Ye ^[3] ; Brian,Hughes ^[1] ; Borui,Zhang ^[1] ; Allancer,Nunes ^[1] ; Kyooa,Lee ^[1] ; Wandi,Xu ^[1] ; Abdalla,Mohamed ^[1] ; Ellie,Piepgras ^[1] ; Sara J,McGowan ^[1] ; Luise,Angelini ^[1] ; Ryan,O'Kelly ^[1] ; Xianlin,Han ^[4] ; Laura J,Niedernhofer ^[1] ; Paul D,Robbins ^[5]

作者单位： Institute on the Biology of Aging and Metabolism and the Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA. ^[1] Institute on the Biology of Aging and Metabolism and the Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.;Department of Medicine and Aging Sciences, University "G. d'Annunzio" of Chieti-Pescara, Chieti, Italy. ^[2] Barshop Institute for Longevity and Aging Studies, San Antonio, TX, USA. ^[3] Barshop Institute for Longevity and Aging Studies, San Antonio, TX, USA.;Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. ^[4] Institute on the Biology of Aging and Metabolism and the Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.;Lead contact. ^[5]

关键词 PUFA aging eleostearic acid fatty acid ferroptosis healthspan lipid senescence senolysis senolytic senotherapeutic

DOI 10.1101/2024.10.14.618023

PMID 39463954

发布时间 2024-11-27

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Identification of lipid senolytics targeting senescent cells through ferroptosis induction.

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Identification of lipid senolytics targeting senescent cells through ferroptosis induction.

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