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N-[4-(Benzyloxy)-3-methoxybenzyl)]adamantane-1-amine (DZH2), a dual CCR5 and CXCR4 inhibitor as a potential agent against triple negative breast cancer.

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第一作者： Monica M,Rostom

第一单位： Department of Pharmacology and Toxicology, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt.

作者： Monica M,Rostom ^[1] ; Mariam A,El-Zohairy ^[2] ; Mohamed A,Marzouk ^[3] ; Martin R,Berger ^[4] ; Dominique,Schols ^[5] ; Reem A,Assal ^[6] ; Yasmine M,Mandour ^[7] ; Hassan,Adwan ^[8] ; Darius P,Zlotos ^[2]

作者单位： Department of Pharmacology and Toxicology, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt. ^[1] Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt. ^[2] Institute of Pharmacy and Food Chemistry, University of Würzburg, Würzburg, Germany. ^[3] Toxicology and Chemotherapy Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany. ^[4] Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium. ^[5] Department of Pharmacology and Toxicology, Faculty of Pharmacy, Heliopolis University for Sustainable Development, Cairo, Egypt. ^[6] School of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation, Cairo, Egypt. ^[7] Department of Pharmacology and Toxicology, Faculty of Medicine, University of Heidelberg, Heidelberg, Germany. ^[8]

关键词 CCR5 CXCR4 breast cancer chemokine receptors virtual screening