Venetoclax dose escalation rapidly activates a BAFF/BCL-2 survival axis in chronic lymphocytic leukemia.

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作者： Meng-Xiao,Luo ^[1] ; Tania,Tan ^[1] ; Marie,Trussart ^[1] ; Annika,Poch ^[2] ; Thi Minh Hanh,Nguyen ^[2] ; Terence P,Speed ^[1] ; Damien G,Hicks ^[3] ; Esther,Bandala-Sanchez ^[1] ; Hongke,Peng ^[1] ; Stéphane,Chappaz ^[4] ; Charlotte,Slade ^[1] ; Daniel T,Utzschneider ^[2] ; Rachel M,Koldej ^[5] ; David,Ritchie ^[6] ; Andreas,Strasser ^[1] ; Rachel,Thijssen ^[1] ; Matthew E,Ritchie ^[1] ; Constantine S,Tam ^[7] ; Geoffrey J,Lindeman ^[8] ; David C S,Huang ^[1] ; Thomas E,Lew ^[9] ; Mary Ann,Anderson ^[9] ; Andrew W,Roberts ^[9] ; Charis E,Teh ^[1] ; Daniel H D,Gray ^[1]

作者单位： The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.;Department of Medical Biology, The University of Melbourne, Melbourne, VIC, Australia. ^[1] Department of Medical Biology, The University of Melbourne, Melbourne, VIC, Australia.;The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia. ^[2] School of Science, Computing and Engineering Technologies, Swinburne University of Technology, Melbourne, VIC, Australia. ^[3] Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia. ^[4] Department of Medical Biology, The University of Melbourne, Melbourne, VIC, Australia.;Australian Cancer Research Foundation Translational Research Laboratory, The Royal Melbourne Hospital, Melbourne, VIC, Australia. ^[5] Department of Medical Biology, The University of Melbourne, Melbourne, VIC, Australia.;Australian Cancer Research Foundation Translational Research Laboratory, The Royal Melbourne Hospital, Melbourne, VIC, Australia.;Department of Haematology, The Royal Melbourne Hospital, Melbourne, VIC, Australia. ^[6] Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.;Alfred Hospital, Melbourne, VIC, Australia. ^[7] The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.;Department of Medical Biology, The University of Melbourne, Melbourne, VIC, Australia.;Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. ^[8] The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.;Department of Medical Biology, The University of Melbourne, Melbourne, VIC, Australia.;Department of Haematology, The Royal Melbourne Hospital, Melbourne, VIC, Australia.;Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. ^[9]