METTL3 confers oxaliplatin resistance through the activation of G6PD-enhanced pentose phosphate pathway in hepatocellular carcinoma.

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第一作者： Xiaohan,Jin

第一单位： State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, PR China.;State Key Laboratory of Respiratory Disease, Institute of Pulmonary Diseases, Department of Oncology, Guangzhou Chest Hospital, Guangzhou Medical University, Guangzhou, PR China.

作者： Xiaohan,Jin ^[1] ; Yongrui,Lv ^[2] ; Fengjie,Bie ^[3] ; Jinling,Duan ^[2] ; Chao,Ma ^[2] ; Miaomiao,Dai ^[2] ; Jiewei,Chen ^[2] ; Lianghe,Lu ^[4] ; Shuidan,Xu ^[2] ; Jie,Zhou ^[2] ; Si,Li ^[2] ; Jiong,Bi ^[5] ; Fengwei,Wang ^[2] ; Dan,Xie ^[6] ; Muyan,Cai ^[7]

作者单位： State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, PR China.;State Key Laboratory of Respiratory Disease, Institute of Pulmonary Diseases, Department of Oncology, Guangzhou Chest Hospital, Guangzhou Medical University, Guangzhou, PR China. ^[1] State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, PR China. ^[2] Breast Disease Specialist Hospital of Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, PR China. ^[3] Department of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China. ^[4] Laboratory of General Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. ^[5] State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, PR China. xiedan@sysucc.org.cn. ^[6] State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, PR China. caimy@sysucc.org.cn. ^[7]

DOI 10.1038/s41418-024-01406-2

PMID 39472692

发布时间 2024-10-30

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METTL3 confers oxaliplatin resistance through the activation of G6PD-enhanced pentose phosphate pathway in hepatocellular carcinoma.

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METTL3 confers oxaliplatin resistance through the activation of G6PD-enhanced pentose phosphate pathway in hepatocellular carcinoma.

Cell death and differentiation

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