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A multi-modal single-cell and spatial expression map of metastatic breast cancer biopsies across clinicopathological features.

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第一作者： Johanna,Klughammer

第一单位： Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA. klughammer@genzentrum.lmu.de.;Gene Center and Department of Biochemistry, Ludwig Maximilians Universität München, Munich, Germany. klughammer@genzentrum.lmu.de.

作者： Johanna,Klughammer ^[1] ; Daniel L,Abravanel ^[2] ; Åsa,Segerstolpe ^[3] ; Timothy R,Blosser ^[4] ; Yury,Goltsev ^[5] ; Yi,Cui ^[6] ; Daniel R,Goodwin ^[6] ; Anubhav,Sinha ^[6] ; Orr,Ashenberg ^[3] ; Michal,Slyper ^[3] ; Sébastien,Vigneau ^[7] ; Judit,Jané-Valbuena ^[3] ; Shahar,Alon ^[8] ; Chiara,Caraccio ^[5] ; Judy,Chen ^[7] ; Ofir,Cohen ^[9] ; Nicole,Cullen ^[10] ; Laura K,DelloStritto ^[7] ; Danielle,Dionne ^[3] ; Janet,Files ^[11] ; Allison,Frangieh ^[7] ; Karla,Helvie ^[7] ; Melissa E,Hughes ^[11] ; Stephanie,Inga ^[7] ; Abhay,Kanodia ^[7] ; Ana,Lako ^[10] ; Colin,MacKichan ^[7] ; Simon,Mages ^[12] ; Noa,Moriel ^[13] ; Evan,Murray ^[14] ; Sara,Napolitano ^[7] ; Kyleen,Nguyen ^[11] ; Mor,Nitzan ^[15] ; Rebecca,Ortiz ^[7] ; Miraj,Patel ^[7] ; Kathleen L,Pfaff ^[10] ; Caroline B M,Porter ^[3] ; Asaf,Rotem ^[16] ; Sarah,Strauss ^[11] ; Robert,Strasser ^[17] ; Aaron R,Thorner ^[7] ; Madison,Turner ^[18] ; Isaac,Wakiro ^[7] ; Julia,Waldman ^[3] ; Jingyi,Wu ^[7] ; Jorge,Gómez Tejeda Zañudo ^[19] ; Diane,Zhang ^[14] ; Nancy U,Lin ^[11] ; Sara M,Tolaney ^[11] ; Eric P,Winer ^[11] ; Edward S,Boyden ^[20] ; Fei,Chen ^[21] ; Garry P,Nolan ^[5] ; Scott J,Rodig ^[22] ; Xiaowei,Zhuang ^[23] ; Orit,Rozenblatt-Rosen ^[24] ; Bruce E,Johnson ^[25] ; Aviv,Regev ^[26] ; Nikhil,Wagle ^[27]

作者单位： Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA. klughammer@genzentrum.lmu.de.;Gene Center and Department of Biochemistry, Ludwig Maximilians Universität München, Munich, Germany. klughammer@genzentrum.lmu.de. ^[1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. daniel_abravanel@dfci.harvard.edu.;Harvard Medical School, Boston, MA, USA. daniel_abravanel@dfci.harvard.edu. ^[2] Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA. ^[3] Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA. ^[4] Baxter Laboratory in Stem Cell Biology, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA. ^[5] Department of Media Arts and Sciences, McGovern Institute, Massachusetts Institute of Technology, Cambridge, MA, USA. ^[6] Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA. ^[7] Department of Media Arts and Sciences, McGovern Institute, Massachusetts Institute of Technology, Cambridge, MA, USA.;Faculty of Engineering, Gonda Brain Research Center and Institute of Nanotechnology, Bar-Ilan University, Ramat Gan, Israel. ^[8] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.;Broad Institute of Harvard and MIT, Cambridge, MA, USA.;Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Guiron University, Beersheba, Israel. ^[9] Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. ^[10] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. ^[11] Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.;Gene Center and Department of Biochemistry, Ludwig Maximilians Universität München, Munich, Germany. ^[12] School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel. ^[13] Broad Institute of Harvard and MIT, Cambridge, MA, USA. ^[14] School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel.;Racah Institute of Physics, The Hebrew University of Jerusalem, Jerusalem, Israel.;Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel. ^[15] Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA.;AstraZeneca R&D, Boston, MA, USA. ^[16] Gene Center and Department of Biochemistry, Ludwig Maximilians Universität München, Munich, Germany. ^[17] Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.;Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA, USA. ^[18] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.;Broad Institute of Harvard and MIT, Cambridge, MA, USA. ^[19] Department of Media Arts and Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.;Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.;Department of Biology, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.;Howard Hughes Medical Institute, Chevy Chase, MD, USA.;Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.;K. Lisa Yang Center for Bionics, Massachusetts Institute of Technology, Cambridge, MA, USA. ^[20] Broad Institute of Harvard and MIT, Cambridge, MA, USA.;Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. ^[21] Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.;Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.;Department of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA. ^[22] Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.;Howard Hughes Medical Institute, Chevy Chase, MD, USA.;Department of Physics, Harvard University, Cambridge, MA, USA. ^[23] Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA.;Genentech, Inc., South San Francisco, CA, USA. ^[24] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.;Harvard Medical School, Boston, MA, USA.;Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA. ^[25] Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA, USA. regev.aviv@gene.com.;Genentech, Inc., South San Francisco, CA, USA. regev.aviv@gene.com. ^[26] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. wagle.nikhil@gene.com.;Harvard Medical School, Boston, MA, USA. wagle.nikhil@gene.com.;Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA. wagle.nikhil@gene.com.;Broad Institute of Harvard and MIT, Cambridge, MA, USA. wagle.nikhil@gene.com.;Genentech, Inc., South San Francisco, CA, USA. wagle.nikhil@gene.com. ^[27]