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RAS-mutant leukaemia stem cells drive clinical resistance to venetoclax.

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第一作者: Junya,Sango
第一单位: Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Center for Advancement of Blood Cancer Therapies, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
作者单位: Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Center for Advancement of Blood Cancer Therapies, Icahn School of Medicine at Mount Sinai, New York, NY, USA. [1] Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Center for Advancement of Blood Cancer Therapies, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Bioinformatics for Next Generation Sequencing Shared Resource Facility, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. [2] Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.;Louis V. Gerstner Jr Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA. [3] Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. [4] Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Center for Advancement of Blood Cancer Therapies, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Bioinformatics for Next Generation Sequencing Shared Resource Facility, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. [5] Department of Medicine, Division of Precision Medicine, NYU Grossman School of Medicine, New York, NY, USA.;Department of Pathology, NYU Grossman School of Medicine, New York, NY, USA. [6] Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.;Medical Scientist Training Program, University of Texas Southwestern Medical Center, Dallas, TX, USA. [7] Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. [8] Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Center for Advancement of Blood Cancer Therapies, Icahn School of Medicine at Mount Sinai, New York, NY, USA. [9] Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.;Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA. [10] Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Center for Advancement of Blood Cancer Therapies, Icahn School of Medicine at Mount Sinai, New York, NY, USA. [11] Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.;New York Genome Center, New York, NY, USA. [12] Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA. [13] Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Center for Advancement of Blood Cancer Therapies, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Bioinformatics for Next Generation Sequencing Shared Resource Facility, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. [14] Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA. [15] Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Center for Advancement of Blood Cancer Therapies, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Bioinformatics for Next Generation Sequencing Shared Resource Facility, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. [16] Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx, NY, USA.;Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA.;Montefiore Einstein Comprehensive Cancer Center, Bronx, NY, USA. [17] Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. eirini.papapetrou@mssm.edu.;Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. eirini.papapetrou@mssm.edu.;Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. eirini.papapetrou@mssm.edu.;Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. eirini.papapetrou@mssm.edu.;Center for Advancement of Blood Cancer Therapies, Icahn School of Medicine at Mount Sinai, New York, NY, USA. eirini.papapetrou@mssm.edu. [18]
DOI 10.1038/s41586-024-08137-x
PMID 39478230
发布时间 2025-07-20
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