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A new approach methodology to identify tumorigenic chemicals using short-term exposures and transcript profiling.

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第一作者： Victoria,Ledbetter

第一单位： Center for Computational Toxicology and Exposure, US Environmental Protection Agency, Durham, NC, United States.;Oak Ridge Associated Universities (ORAU), Oak Ridge, TN, United States.

作者： Victoria,Ledbetter ^[1] ; Scott,Auerbach ^[2] ; Logan J,Everett ^[3] ; Beena,Vallanat ^[3] ; Anna,Lowit ^[4] ; Gregory,Akerman ^[4] ; William,Gwinn ^[2] ; Leah C,Wehmas ^[3] ; Michael F,Hughes ^[3] ; Michael,Devito ^[3] ; J Christopher,Corton ^[3]

作者单位： Center for Computational Toxicology and Exposure, US Environmental Protection Agency, Durham, NC, United States.;Oak Ridge Associated Universities (ORAU), Oak Ridge, TN, United States. ^[1] National Institute of Environmental Health Sciences (NIEHS), Division of Translational Toxicology, Durham, NC, United States. ^[2] Center for Computational Toxicology and Exposure, US Environmental Protection Agency, Durham, NC, United States. ^[3] U.S. Environmental Protection Agency, Office of Pesticide Programs, Washington, DC, United States. ^[4]

关键词 2-year cancer bioassay adverse outcome pathway biomarkers liver cancer new approach methodologies transcript profiling

DOI 10.3389/ftox.2024.1422325

PMID 39483698

发布时间 2024-11-02

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A new approach methodology to identify tumorigenic chemicals using short-term exposures and transcript profiling.

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A new approach methodology to identify tumorigenic chemicals using short-term exposures and transcript profiling.

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