Ascitic Shear Stress Activates GPCRs and Downregulates Mucin 15 to Promote OvarianCancer Malignancy.

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作者： Geeta,Mehta ^[1] ; Eric,Horst ^[1] ; Liam,Cotter ^[1] ; Mia,Bonini ^[1] ; Caymen,Novak ^[1] ; Nina,Treacher ^[1] ; Yeye,Zhang ^[1] ; Zoe,Jackson ^[1] ; Ishwarya Venkata,Narayanan ^[2] ; Fulei,Wuchu ^[1] ; Minal,Nenwani ^[1] ; Zachary,Fischer ^[1] ; Alec,Sunshine ^[1] ; Zequan,Lin ^[1] ; Linh,Tran ^[1] ; Deepak,Nagrath ^[1] ; Mats,Ljungman ^[1] ; Katherine,Maturen ^[1] ; Analisa,DiFeo ^[1] ; David,Nordsletten ^[1]

作者单位： University of Michigan. ^[1] University of Michigan-Ann Arbor. ^[2]

关键词 G-protein coupled receptors (GPCR)NF-κB PLCβ ascitic currents epithelial to mesenchymal transition (EMT)fluid shear stress glycocalyx high grade serous ovarian cancer mechanotransduction mucin 15 (MUC15)transcoelomic metastasis

DOI 10.21203/rs.3.rs-5160301/v1

PMID 39483899

发布时间 2024-12-04

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Ascitic Shear Stress Activates GPCRs and Downregulates Mucin 15 to Promote OvarianCancer Malignancy.

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Ascitic Shear Stress Activates GPCRs and Downregulates Mucin 15 to Promote OvarianCancer Malignancy.

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