Prognostic and predictive factors for the efficacy and safety of trastuzumab deruxtecan in HER2-positive gastric or gastroesophageal junction cancer.

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第一作者： Amane,Jubashi

第一单位： Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.;Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki City, Nagasaki, 852-8501, Japan.

作者： Amane,Jubashi ^[1] ; Izuma,Nakayama ^[2] ; Shigehiro,Koganemaru ^[3] ; Naoya,Sakamoto ^[4] ; Shioto,Oda ^[5] ; Yuki,Matsubara ^[6] ; Yu,Miyashita ^[6] ; Seiya,Sato ^[6] ; Shinpei,Ushiyama ^[6] ; Akinori,Kobayashi ^[6] ; Ukyo,Okazaki ^[6] ; Dai,Okemoto ^[6] ; Kazumasa,Yamamoto ^[6] ; Saori,Mishima ^[6] ; Daisuke,Kotani ^[6] ; Akihito,Kawazoe ^[6] ; Tadayoshi,Hashimoto ^[7] ; Yoshiaki,Nakamura ^[7] ; Yasutoshi,Kuboki ^[8] ; Hideaki,Bando ^[6] ; Takashi,Kojima ^[6] ; Takayuki,Yoshino ^[6] ; Hisamitsu,Miyaaki ^[9] ; Kazuhiko,Nakao ^[9] ; Kohei,Shitara ^[6]

作者单位： Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.;Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki City, Nagasaki, 852-8501, Japan. ^[1] Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan. iznakaya@east.ncc.go.jp. ^[2] Department of Experimental Therapeutics, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan. ^[3] Department of Pathology and Clinical Laboratories, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.;Division of Pathology, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, 277-8577, Japan. ^[4] Department of Diagnostic Radiology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan. ^[5] Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan. ^[6] Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.;Translational Research Support Section, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan. ^[7] Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.;Department of Experimental Therapeutics, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan. ^[8] Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki City, Nagasaki, 852-8501, Japan. ^[9]

关键词 Gastric cancer Interstitial lung disease Optimize dosing Trastuzumab deruxtecan Tumor burden