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One stone two birds: Introducing piperazine into a series of nucleoside derivatives as potent and selective PRMT5 inhibitors.

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作者: Huaxuan,Li [1] ; Hong,Yang [2] ; Li,Liu [3] ; Jiahong,Zheng [3] ; Qiongyu,Shi [2] ; Bang,Li [3] ; Xingcan,Wang [4] ; Ying,Zhang [5] ; Ruilin,Zhou [6] ; Jian,Zhang [7] ; Zhong-Zhu,Chen [8] ; Chang-Yun,Wang [9] ; Yuanxiang,Wang [10] ; Xun,Huang [11] ; Zhiqing,Liu [12]
作者单位: MOE Key Laboratory of Marine Drugs and Key Laboratory of Evolution and Marine Biodiversity, School of Medicine and Pharmacy, Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao, 266003, China; Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao, 266237, China; Balance-Based Drug Discovery Laboratory, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China. [1] Lingang Laboratory, Shanghai, 200031, China. [2] Balance-Based Drug Discovery Laboratory, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China. [3] Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, China. [4] Lingang Laboratory, Shanghai, 200031, China; School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. [5] School of Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210023, China. [6] Thoracic Surgery Department, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, China. [7] College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing University of Arts and Sciences, Chongqing, 402160, China. [8] MOE Key Laboratory of Marine Drugs and Key Laboratory of Evolution and Marine Biodiversity, School of Medicine and Pharmacy, Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao, 266003, China; Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao, 266237, China. Electronic address: changyun@ouc.edu.cn. [9] Balance-Based Drug Discovery Laboratory, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China. Electronic address: wangyx95@mail.sysu.edu.cn. [10] Lingang Laboratory, Shanghai, 200031, China; School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China; School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai, 200240, China; School of Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210023, China. Electronic address: xhuang@simm.ac.cn. [11] MOE Key Laboratory of Marine Drugs and Key Laboratory of Evolution and Marine Biodiversity, School of Medicine and Pharmacy, Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao, 266003, China; Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao, 266237, China. Electronic address: liuzhiqing@ouc.edu.cn. [12]
DOI 10.1016/j.ejmech.2024.116970
PMID 39488968
发布时间 2024-12-05
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