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Glycyrrhizic acid and patchouli alcohol in Huoxiang Zhengqi attenuate intestinal inflammation and barrier injury via regulating endogenous corticosterone metabolism mediated by 11β-HSD1.

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作者: Yangyang,Wang [1] ; Chuying,Sun [2] ; Yutang,Cao [2] ; Tingying,Jiao [3] ; Kanglong,Wang [4] ; Jiaqi,Li [5] ; Mengjiao,Zhang [2] ; Jie,Jiang [6] ; Xianchun,Zhong [4] ; Shuwu,Yu [4] ; Hualing,Xu [2] ; Jiawen,Wang [4] ; Tong,Yi [7] ; Xiaoting,Tian [4] ; Haiyan,Zhu [7] ; Haifeng,Zhou [8] ; Chenggang,Huang [9] ; Tong,Wu [10] ; Xiaozhen,Guo [11] ; Cen,Xie [12]
作者单位: National Key Laboratory of Lead Druggability Research, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai, 201203, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. [1] School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China. [2] State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; State Key Laboratory of Genetic Engineering, School of Life Sciences, Human Phenome Institute, Fudan University, Shanghai, 200032, China. [3] State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. [4] State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; University of Chinese Academy of Sciences, Beijing, 100049, China. [5] Division of Nephrology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. [6] Department of Biological Medicines & Shanghai Engineering Research Center of Immunotherapeutics, School of Pharmacy, Fudan University, Shanghai, 200032, China. [7] National Key Laboratory of Lead Druggability Research, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai, 201203, China. [8] State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. Electronic address: cghuang@simm.ac.cn. [9] National Key Laboratory of Lead Druggability Research, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai, 201203, China. Electronic address: wutong1@sinopharm.com. [10] State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. Electronic address: guoxz@simm.ac.cn. [11] State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China; University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address: xiecen@simm.ac.cn. [12]
DOI 10.1016/j.jep.2024.119025
PMID 39489360
发布时间 2024-12-06
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