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DNA Sensor ABCF1 Phase Separates With cccDNA to Inhibit Hepatitis B Virus Replication.

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第一作者： Caiyue,Ren

第一单位： Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Cheeloo Medical College, Shandong University, Jinan, Shandong, 250012, China.

作者： Caiyue,Ren ^[1] ; Zhaoying,Zhang ^[1] ; Yutong,Dou ^[1] ; Yang,Sun ^[1] ; Zhendong,Fu ^[1] ; Liyuan,Wang ^[1] ; Kai,Wang ^[1] ; Chengjiang,Gao ^[1] ; Yuchen,Fan ^[2] ; Shuguo,Sun ^[3] ; Xuetian,Yue ^[4] ; Chunyang,Li ^[5] ; Lifen,Gao ^[1] ; Xiaohong,Liang ^[1] ; Chunhong,Ma ^[1] ; Zhuanchang,Wu ^[1]

作者单位： Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Cheeloo Medical College, Shandong University, Jinan, Shandong, 250012, China. ^[1] Department of Hepatology, Qilu Hospital, Cheeloo Medical College, Shandong University, Jinan, Shandong, 250012, China. ^[2] Department of Human Anatomy, Histology and Embryology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China. ^[3] Department of Cellular Biology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong, 250012, China. ^[4] Key Laboratory for Experimental Teratology of the Ministry of Education, Department of Histology and Embryology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong, 250012, China. ^[5]

关键词 ABCF1 HBV HBx cccDNA phase separation transcriptional machinery

医学主题词乙型肝炎病毒(Hepatitis B virus);病毒复制(Virus Replication);人类(Humans);DNA, 环状(DNA, Circular);DNA, 病毒(DNA, Viral)

DOI 10.1002/advs.202409485

PMID 39498874

发布时间 2026-03-04

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