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Identification of potential inhibitors for MAP4K4 in glaucoma using meta-dynamics-based dissociation free energy calculation.

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第一作者： Vanshika,Rustagi

第一单位： Department of Biotechnology, School of Engineering and Technology, Manav Rachna International Institute of Research and Studies, Faridabad, Haryana 121004, India.

作者： Vanshika,Rustagi ^[1] ; Rashmi,Rameshwari ^[2] ; Indrakant,Kumar Singh ^[3]

作者单位： Department of Biotechnology, School of Engineering and Technology, Manav Rachna International Institute of Research and Studies, Faridabad, Haryana 121004, India. ^[1] Department of Biotechnology, School of Engineering and Technology, Manav Rachna International Institute of Research and Studies, Faridabad, Haryana 121004, India. Electronic address: rashmi.set@mriu.edu.in. ^[2] Molecular Biology Research Lab, Department of Zoology, Deshbandhu College, University of Delhi, Kalkaji, New Delhi 110019, India; Delhi School of Public Health, Institute of Eminence, University of Delhi, Delhi 110007, India. Electronic address: iksingh@db.du.ac.in. ^[3]

关键词 Blindness Glaucoma HGK Human health IOP Inhibitor MAP4K4 NIK Oxidative stress Retinal ganglionic cells Treatment

医学主题词人类(Humans);青光眼(Glaucoma);分子动力学模拟(Molecular Dynamics Simulation);氧化性应激(Oxidative Stress);蛋白激酶抑制剂(Protein Kinase Inhibitors);细胞内信号肽和蛋白质类(Intracellular Signaling Peptides and Proteins)

DOI 10.1016/j.brainres.2024.149300

PMID 39500479

发布时间 2024-12-08

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