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High incidence and geographic distribution of cleft palate in Finland are associated with the IRF6 gene.

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第一作者: Fedik,Rahimov
第一单位: Department of Human Genetics, Genomics Research Center, AbbVie Inc, North Chicago, IL, 60064, USA.
作者单位: Department of Human Genetics, Genomics Research Center, AbbVie Inc, North Chicago, IL, 60064, USA. [1] Orthodontics, Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, 00014, Finland. [2] Department of Anatomy and Cell Biology, University of Iowa, Iowa City, IA, 52242, USA.;Department of Oral Health Sciences, University of Washington, Seattle, WA, 98195, USA. [3] Orthodontics, Department of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, 00014, Finland.;Cleft Palate and Craniofacial Center, Department of Plastic Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, 00029 HUS, Finland. [4] Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, 51010, Estonia. [5] Environmental Genomics and Systems Biology Division, Lawrence Berkeley Laboratories, Berkeley, CA, 94720, USA.;U.S. Department of Energy Joint Genome Institute, Lawrence Berkeley Laboratories, Berkeley, CA, 94720, USA. [6] Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, 00014, Finland.;Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA. [7] Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, 00014, Finland. [8] Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, 51010, Estonia.;Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, 00014, Finland. [9] Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, 00014, Finland.;Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.;Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, 02114, USA. [10] Cleft Palate and Craniofacial Center, Department of Plastic Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, 00029 HUS, Finland. [11] Department of Oral Health Sciences, University of Washington, Seattle, WA, 98195, USA.;Department of Biochemistry, University of Washington School of Medicine, Seattle, WA, 98195, USA.;Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA, 98109, USA.;Cancer Biology and Stem Cell Biology Laboratory, Department of Genetic Engineering, School of Bioengineering, College of Engineering and Technology, SRM Institute of Science and Technology, Chennai, 603203, India. [12] Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA, 98109, USA.;UW Medicine South Lake Union, University of Washington, Seattle, WA, 98109, USA. [13] Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA, 98109, USA.;UW Medicine South Lake Union, University of Washington, Seattle, WA, 98109, USA.;Matchstick Technologies, Inc, Kirkland, WA, 98033, USA. [14] Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA, 98109, USA.;Department of Comparative Medicine, University of Washington School of Medicine, Seattle, WA, 98195, USA. [15] Department of Oral Health Sciences, University of Washington, Seattle, WA, 98195, USA.;Department of Biochemistry, University of Washington School of Medicine, Seattle, WA, 98195, USA.;Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA, 98109, USA.;Brotman Baty Institute for Precision Medicine, Seattle, WA, 98195, USA.;Department of Bioengineering, University of Washington, Seattle, WA, 98195, USA. [16] Environmental Genomics and Systems Biology Division, Lawrence Berkeley Laboratories, Berkeley, CA, 94720, USA.;U.S. Department of Energy Joint Genome Institute, Lawrence Berkeley Laboratories, Berkeley, CA, 94720, USA.;School of Natural Sciences, University of California, Merced, CA, 95343, USA. [17] Department of Diagnostic and Biomedical Sciences, School of Dentistry, University of Texas Health Science Center at Houston, Houston, TX, 77054, USA.;Department of Pediatrics, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA. [18] Department of Microbiology, Genetics and Immunology, College of Osteopathic Medicine, Michigan State University, East Lansing, MI, 48824, USA. schutteb@msu.edu. [19] Department of Anatomy and Cell Biology, University of Iowa, Iowa City, IA, 52242, USA. cornellr@uw.edu.;Department of Oral Health Sciences, University of Washington, Seattle, WA, 98195, USA. cornellr@uw.edu.;Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA, 98109, USA. cornellr@uw.edu. [20] Orthodontics, Department of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, 00014, Finland. david.rice@helsinki.fi. [21]
DOI 10.1038/s41467-024-53634-2
PMID 39500877
发布时间 2025-05-27
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