Optimizing CAR-T cell therapy for solid tumors: current challenges and potential strategies.

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作者： Kexin,Ai ^[1] ; Bowen,Liu ^[2] ; Xiaomei,Chen ^[2] ; Chuxin,Huang ^[1] ; Liping,Yang ^[1] ; Weiya,Zhang ^[3] ; Jianyu,Weng ^[2] ; Xin,Du ^[2] ; Kongming,Wu ^[4] ; Peilong,Lai ^[5]

作者单位： Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, Guangdong, China. ^[1] Department of Hematology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Road, Guangzhou, 510280, Guangdong, China. ^[2] Princess Máxima Center for Pediatric Oncology, 3584 CS, Utrecht, The Netherlands. ^[3] Cancer Center, Shanxi Bethune Hospital, Shanxi Academy of Medical Science, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032, China. wukm_lab@163.com.;Cancer Center, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, China. wukm_lab@163.com. ^[4] Department of Hematology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Er Road, Guangzhou, 510280, Guangdong, China. lai_peilong@163.com. ^[5]

关键词 CAR-T cell therapy Challenges of cytotoxicity Novel technologies Restriction in application Solid tumors

主题词人类(Humans);免疫疗法, 过继(Immunotherapy, Adoptive);肿瘤(Neoplasms);T淋巴细胞(T-Lymphocytes);动物(Animals)

DOI 10.1186/s13045-024-01625-7

PMID 39501358

发布时间 2024-11-08

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