The third generation AKR1C3-activated prodrug, ACHM-025, eradicates disease in preclinical models of aggressive T-cell acute lymphoblastic leukemia.

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作者： Cara E,Toscan ^[1] ; Hannah,McCalmont ^[1] ; Amir,Ashoorzadeh ^[2] ; Xiaojing,Lin ^[2] ; Zhe,Fu ^[3] ; Louise,Doculara ^[1] ; Hansen J,Kosasih ^[1] ; Roxanne,Cadiz ^[1] ; Anthony,Zhou ^[1] ; Sarah,Williams ^[1] ; Kathryn,Evans ^[1] ; Faezeh,Khalili ^[1] ; Ruilin,Cai ^[1] ; Kristy L,Yeats ^[1] ; Andrew J,Gifford ^[4] ; Russell,Pickford ^[5] ; Chelsea,Mayoh ^[1] ; Jinhan,Xie ^[1] ; Michelle J,Henderson ^[1] ; Toby N,Trahair ^[6] ; Adam V,Patterson ^[2] ; Jeff B,Smaill ^[2] ; Charles E,de Bock ^[1] ; Richard B,Lock ^[7]

作者单位： Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia. ^[1] Auckland Cancer Society Research Centre, University of Auckland, Auckland, New Zealand.;Maurice Wilkins Centre for Molecular Biodiscovery, School of Biological Sciences, University of Auckland, Auckland, New Zealand. ^[2] Maurice Wilkins Centre for Molecular Biodiscovery, School of Biological Sciences, University of Auckland, Auckland, New Zealand.;Malaghan Institute of Medical Research, Wellington, New Zealand. ^[3] Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia.;Anatomical Pathology, NSW Health Pathology, Prince of Wales Hospital, Randwick, NSW, Australia. ^[4] Bioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, UNSW Sydney, Sydney, NSW, Australia. ^[5] Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia.;Kids Cancer Centre, Sydney Children's Hospital, Randwick, NSW, Australia. ^[6] Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia. rlock@ccia.org.au. ^[7]