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A prospective multi-cohort study identifies and validates a 5-gene peripheral blood signature predictive of immunotherapy response in non-small cell lung cancer.

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第一作者： Shaoqiu,Chen

第一单位： Department of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii at Manoa, 651 Ilalo St, Honolulu, HI, 96813, USA.;Molecular Biosciences and Bioengineering Program, College of Tropical Agriculture and Human Resources, University of Hawaii at Manoa, Honolulu, Hawaii, USA.

作者： Shaoqiu,Chen ^[1] ; Fangfang,Liu ^[2] ; Yuanyuan,Fu ^[3] ; Chris K,Deng ^[3] ; Jeffrey A,Borgia ^[4] ; Abdul-Ghani,Ayman ^[5] ; Masaki,Nasu ^[3] ; Mayumi,Jijiwa ^[3] ; Hua,Yang ^[3] ; Ting,Gong ^[1] ; Junlong,Wang ^[1] ; Zhougui,Ling ^[6] ; Xiaoyan,Wang ^[7] ; Hongwei,Wang ^[8] ; Qian,Chu ^[9] ; Youping,Deng ^[10]

作者单位： Department of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii at Manoa, 651 Ilalo St, Honolulu, HI, 96813, USA.;Molecular Biosciences and Bioengineering Program, College of Tropical Agriculture and Human Resources, University of Hawaii at Manoa, Honolulu, Hawaii, USA. ^[1] Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. ^[2] Department of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii at Manoa, 651 Ilalo St, Honolulu, HI, 96813, USA. ^[3] Diagnostic Radiology, Rush University Medical Center, Chicago, Illinois, USA. ^[4] Department of Surgery, John A. Burns School of Medicine, University of Hawaii and Research Laboratory at the Queen's Medical Center, Honolulu, Hawaii, USA. ^[5] Department of Pulmonary and Critical Care Medicine, the Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, China. ^[6] Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China. ^[7] School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China. whw7037@126.com. ^[8] Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. qianchu@tjh.tjmu.edu.cn. ^[9] Department of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii at Manoa, 651 Ilalo St, Honolulu, HI, 96813, USA. dengy@hawaii.edu. ^[10]

关键词 Blood-based Clinical utility ICIs NSCLC Predictive biomarkers

医学主题词人类(Humans);癌, 非小细胞肺(Carcinoma, Non-Small-Cell Lung);肺肿瘤(Lung Neoplasms);男(雄)性(Male);女(雌)性(Female);老年人(Aged);前瞻性研究(Prospective Studies);中年人(Middle Aged);基因表达谱(Gene Expression Profiling);免疫疗法(Immunotherapy);预后(Prognosis);治疗结果(Treatment Outcome);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);老年人, 80以上(Aged, 80 and over);队列研究(Cohort Studies)

DOI 10.1186/s12943-024-02160-2

PMID 39506771

发布时间 2026-06-26

基金项目

P20 GM103466/GM/NIGMS NIH HHS/United States U54 GM138062/GM/NIGMS NIH HHS/United States U54 MD007601/MD/NIMHD NIH HHS/United States P20GM103466, U54MD007601, U54GM138062, U54HG013243 and 1OT2OD032581-02-PP90/NH/NIH HHS/United States

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