Challenging a decades-old paradigm: ProB and ProA do not channel the unstable intermediate in proline synthesis after all.

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第一作者： Matilda S,Newton

第一单位： Department of Molecular, Cellular and Developmental Biology and the Cooperative Institute for Research in Environmental Sciences, University of Colorado, Boulder, CO 80309.;Royal Society Te Aparangi, Wellington 6140, New Zealand.

作者： Matilda S,Newton ^[1] ; Ashley L,Azadeh ^[2] ; Andrew B,Morgenthaler ^[3] ; Shelley D,Copley ^[2]

作者单位： Department of Molecular, Cellular and Developmental Biology and the Cooperative Institute for Research in Environmental Sciences, University of Colorado, Boulder, CO 80309.;Royal Society Te Aparangi, Wellington 6140, New Zealand. ^[1] Department of Molecular, Cellular and Developmental Biology and the Cooperative Institute for Research in Environmental Sciences, University of Colorado, Boulder, CO 80309. ^[2] Department of Molecular, Cellular and Developmental Biology and the Cooperative Institute for Research in Environmental Sciences, University of Colorado, Boulder, CO 80309.;Amyris Inc., Emeryville, CA 94608. ^[3]

关键词 ProA ProB channeling proline synthesis γ-glutamyl phosphate

主题词脯氨酸(Proline);大肠杆菌(Escherichia coli);大肠杆菌蛋白质类(Escherichia coli Proteins);催化域(Catalytic Domain);细菌蛋白质类(Bacterial Proteins);磷酸转移酶类(羧基族体)(Phosphotransferases (Carboxyl Group Acceptor))

DOI 10.1073/pnas.2413673121

PMID 39514317

发布时间 2024-11-21

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