Raddeanin A suppresses intracellular <sup>5</sup>Methylcytosine DNA modification engaged the metastasis of hepatocellular carcinoma.

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作者： Xin,Liu ^[1] ; Xiaoyan,Xie ^[2] ; Kangyu,Wang ^[3] ; Xiaokang,Liu ^[4] ; Jiyu,Gong ^[5] ; Zizhao,Yang ^[6] ; Jiannan,Li ^[7]

作者单位： Key Laboratory of Chinese Medicine Analysis, School of Pharmaceutical Sciences, Changchun University of Chinese Medicine, Changchun, 130117, China; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China; Department of General Surgery, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, 200137, China; Postgraduate School, Jilin Normal University, Siping, 136000, China. ^[1] Department of Pharmacy, The 3rd Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, 130117, China. ^[2] Key Laboratory of Chinese Medicine Analysis, School of Pharmaceutical Sciences, Changchun University of Chinese Medicine, Changchun, 130117, China; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China; Department of General Surgery, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, 200137, China. ^[3] Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, 528400, China. ^[4] Key Laboratory of Chinese Medicine Analysis, School of Pharmaceutical Sciences, Changchun University of Chinese Medicine, Changchun, 130117, China. ^[5] School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China; Department of General Surgery, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, 200137, China. Electronic address: zzyang@shutcm.edu.cn. ^[6] Key Laboratory of Chinese Medicine Analysis, School of Pharmaceutical Sciences, Changchun University of Chinese Medicine, Changchun, 130117, China. Electronic address: lijiannan2007@126.com. ^[7]

关键词 DNA methyltransferase (DNMT)Hepatocellular carcinoma (HCC)Pharmacodynamic effect Raddeanin a (RA)Tumorigenesis and metastasis