Design, Synthesis, and Evaluation of Doxifluridine Derivatives as Nitroreductase-Responsive Anticancer Prodrugs.

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作者： Xinmeng,Zhang ^[1] ; Taimin,Dong ^[1] ; Xu,Li ^[1] ; Changjie,Xu ^[1] ; Fanghui,Chen ^[1] ; Shiben,Wang ^[1] ; Xuekun,Wang ^[1]

作者单位： National Key Laboratory of Macromolecular Drug Development and Manufacturing, School of Pharmaceutical Sciences and Food Engineering, Liaocheng University, 1 Hunan Street, Liaocheng 252059, China. ^[1]

关键词 doxifluridine derivatives nitroreductase prodrug tumor microenvironment

主题词药物前体(Prodrugs);氟尿苷(Floxuridine);硝基还原酶类(Nitroreductases);人类(Humans);抗肿瘤药(Antineoplastic Agents);动物(Animals);药物设计(Drug Design);细胞系, 肿瘤(Cell Line, Tumor);小鼠(Mice);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.3390/molecules29215077

PMID 39519718

发布时间 2024-11-16

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Molecules (Basel, Switzerland)

2024年29卷21期

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Design, Synthesis, and Evaluation of Doxifluridine Derivatives as Nitroreductase-Responsive Anticancer Prodrugs.

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Design, Synthesis, and Evaluation of Doxifluridine Derivatives as Nitroreductase-Responsive Anticancer Prodrugs.

Molecules (Basel, Switzerland)

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Molecules (Basel, Switzerland)

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