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The engagement of Ras/Raf/MEK/ERK and PLCγ1/PKC pathways regulated by TrkB receptor in resistance of glioma cells to elimination upon apoptosis induction.

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第一作者： Adrian,Zając

第一单位： Department of Functional Anatomy and Cytobiology, Institute of Biological Sciences, Maria Curie-Skłodowska University, Akademicka 19, 20-033, Lublin, Poland. Electronic address: adrian.zajac@umcs.pl.

作者： Adrian,Zając ^[1] ; Joanna,Sumorek-Wiadro ^[2] ; Aleksandra,Maciejczyk ^[3] ; Michał,Chojnacki ^[4] ; Iwona,Wertel ^[5] ; Wojciech,Rzeski ^[6] ; Joanna,Jakubowicz-Gil ^[7]

作者单位： Department of Functional Anatomy and Cytobiology, Institute of Biological Sciences, Maria Curie-Skłodowska University, Akademicka 19, 20-033, Lublin, Poland. Electronic address: adrian.zajac@umcs.pl. ^[1] Department of Functional Anatomy and Cytobiology, Institute of Biological Sciences, Maria Curie-Skłodowska University, Akademicka 19, 20-033, Lublin, Poland. Electronic address: joanna.sumorek-wiadro@umcs.pl. ^[2] Independent Unit of Tissue Engineering and Regenerative Medicine, Medical University of Lublin, Chodźki 1, 20-093, Lublin, Poland. Electronic address: aleksandra.maciejczyk@umlub.pl. ^[3] Department of Medical Biology, Institute of Rural Health, Jaczewskiego 2, 20-950, Lublin, Poland. Electronic address: chojnacki.michal@imw.lublin.pl. ^[4] Independent Laboratory of Cancer Diagnostics and Immunology Medical University of Lublin, Chodźki 1, 20-093, Lublin, Poland. Electronic address: iwona.wertel@umlub.pl. ^[5] Department of Functional Anatomy and Cytobiology, Institute of Biological Sciences, Maria Curie-Skłodowska University, Akademicka 19, 20-033, Lublin, Poland; Department of Medical Biology, Institute of Rural Health, Jaczewskiego 2, 20-950, Lublin, Poland. Electronic address: wojciech.rzeski@umcs.pl. ^[6] Department of Functional Anatomy and Cytobiology, Institute of Biological Sciences, Maria Curie-Skłodowska University, Akademicka 19, 20-033, Lublin, Poland. Electronic address: joanna.jakubowicz-gil@umcs.pl. ^[7]

关键词 Cancers intracellular signaling LOXO-101 Malignant gliomas Survival signals inhibitors U-73122