New insights into CAR T-cell hematological toxicities: manifestations, mechanisms, and effective management strategies.

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第一作者： Yuanyuan,Yang

第一单位： Jiangxi Provincial Key Laboratory of Hematological Diseases, Department of Hematology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.

作者： Yuanyuan,Yang ^[1] ; Hongwei,Peng ^[2] ; Jianxiang,Wang ^[3] ; Fei,Li ^[4]

作者单位： Jiangxi Provincial Key Laboratory of Hematological Diseases, Department of Hematology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China. ^[1] Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China. ^[2] State Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, National Clinical Research Center for Blood Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China. ^[3] Jiangxi Provincial Key Laboratory of Hematological Diseases, Department of Hematology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China. yx021021@sina.com.;Jiangxi Clinical Research Center for Hematologic Disease, Nanchang, Jiangxi, China. yx021021@sina.com.;Institute of Lymphoma and Myeloma, Nanchang University, Nanchang, Jiangxi, China. yx021021@sina.com. ^[4]

关键词 B-cell aplasia CAR T-cell therapy Chimeric antigen receptor (CAR)Coagulopathy Cytopenias HLH Hematological toxicity

DOI 10.1186/s40164-024-00573-9

PMID 39521987

发布时间 2024-11-16

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