LRRC45 accelerates bladder cancer development and ferroptosis inhibition via stabilizing NRF2 by competitively KEAP1 interaction.

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第一作者： Linwei,Fan

第一单位： Department of Transfusion Medicine, Key Laboratory of Jiangxi Province for Transfusion Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China.

作者： Linwei,Fan ^[1] ; Dingfan,Guo ^[2] ; Chao,Zhu ^[1] ; Chenqi,Gao ^[1] ; Yu,Wang ^[1] ; Fang,Yin ^[1] ; Mengwei,Liu ^[1] ; Yanyu,Zhou ^[2] ; Tiancheng,Wei ^[1] ; Xinxin,Xiong ^[3] ; Kuai,Yu ^[4] ; Aiping,Le ^[5]

作者单位： Department of Transfusion Medicine, Key Laboratory of Jiangxi Province for Transfusion Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China. ^[1] The First Clinical Medical School of Nanchang University, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China. ^[2] Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China. Electronic address: xiongxinxin@gdph.org.cn. ^[3] Department of Transfusion Medicine, Key Laboratory of Jiangxi Province for Transfusion Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China. Electronic address: yukuai1949@foxmail.com. ^[4] Department of Transfusion Medicine, Key Laboratory of Jiangxi Province for Transfusion Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China. Electronic address: ndyfy00973@ncu.edu.cn. ^[5]

关键词 Bladder cancer Ferroptosis KEAP1/NRF2 LRRC45 Ubiquitination