The dichotomous roles of microbial-modified bile acids 7-oxo-DCA and isoDCA in intestinal tumorigenesis.

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作者： Xingchen,Dong ^[1] ; Fei,Sun ^[1] ; Henry,Secaira-Morocho ^[2] ; Alisa,Hui ^[3] ; Ke,Wang ^[1] ; Chunmiao,Cai ^[1] ; Shirsa,Udgata ^[4] ; Brian,Low ^[3] ; Songlin,Wei ^[1] ; Xinyi,Chen ^[1] ; Ming,Qi ^[1] ; Cheri A,Pasch ^[4] ; Wei,Xu ^[5] ; Jiaoyang,Jiang ^[1] ; Qiyun,Zhu ^[2] ; Tao,Huan ^[3] ; Dustin A,Deming ^[6] ; Ting,Fu ^[7]

作者单位： Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705. ^[1] School of Life Science, Arizona State University, Tempe, AZ 85287. ^[2] Department of Chemistry, University of British Columbia, Vancouver, BC V6T 1Z1, Canada. ^[3] Division of Hematology and Oncology, Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705. ^[4] McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison, Madison, WI 53705.;School of Medicine and Public Health, University of Wisconsin Carbone Cancer Center, Madison, WI 53792. ^[5] Division of Hematology and Oncology, Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705.;McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison, Madison, WI 53705.;School of Medicine and Public Health, University of Wisconsin Carbone Cancer Center, Madison, WI 53792. ^[6] Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705.;School of Medicine and Public Health, University of Wisconsin Carbone Cancer Center, Madison, WI 53792. ^[7]

关键词 bile acids colorectal cancer nuclear receptor FXR