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Mutant PP2A Induces IGFBP2 Secretion to Promote Development of High-Grade Uterine Cancer.

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第一作者： Terrance J,Haanen

第一单位： Department of Cancer Biology, University of Michigan, Ann Arbor, Michigan.;Division of Genetic Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.

作者： Terrance J,Haanen ^[1] ; Sophie,Boock ^[2] ; Catherine G,Callahan ^[2] ; Irene,Peris ^[2] ; Kaitlin P,Zawacki ^[2] ; Brynne,Raines ^[3] ; Charles A,Nino ^[3] ; Brian,Tran ^[4] ; Alexis,Harold ^[1] ; Gabrielle,Hodges Onishi ^[2] ; Matthew,Hinderman ^[2] ; Amanda,Dowdican ^[2] ; Wei,Huang ^[5] ; Derek J,Taylor ^[5] ; Sarah E,Taylor ^[6] ; Mark W,Jackson ^[6] ; Analisa,DiFeo ^[7] ; Caitlin M,O'Connor ^[8] ; Goutham,Narla ^[8]

作者单位： Department of Cancer Biology, University of Michigan, Ann Arbor, Michigan.;Division of Genetic Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan. ^[1] Division of Genetic Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan. ^[2] Division of Genetic Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.;Department of Cellular and Molecular Biology, University of Michigan, Ann Arbor, Michigan. ^[3] Division of Genetic Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.;Department of Pharmacology, University of Michigan, Ann Arbor, Michigan. ^[4] Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio.;Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio. ^[5] Department of Pathology, Case Western Reserve University, Cleveland, Ohio. ^[6] Rogel Cancer Center, University of Michigan Health, Ann Arbor, Michigan.;Department of Pathology, University of Michigan, Ann Arbor, Michigan.;Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan. ^[7] Division of Genetic Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.;Rogel Cancer Center, University of Michigan Health, Ann Arbor, Michigan. ^[8]

医学主题词女(雌)性(Female);蛋白质磷酸酶2(Protein Phosphatase 2);人类(Humans);子宫肿瘤(Uterine Neoplasms);动物(Animals);小鼠(Mice);胰岛素样生长因子结合蛋白质2(Insulin-Like Growth Factor Binding Protein 2);突变(Mutation);癌肉瘤(Carcinosarcoma);细胞系, 肿瘤(Cell Line, Tumor);囊腺癌, 浆液(Cystadenocarcinoma, Serous);信号传导(Signal Transduction);上皮-间质转化(Epithelial-Mesenchymal Transition)

DOI 10.1158/0008-5472.CAN-24-1263

PMID 39531506

发布时间 2026-03-07

基金项目

F31-CA271463/National Cancer Institute (NCI) R01 CA260200/CA/NCI NIH HHS/United States T32 CA009676/CA/NCI NIH HHS/United States R01 CA240993/CA/NCI NIH HHS/United States R21-CA27397901/National Cancer Institute (NCI) P30 CA046592/CA/NCI NIH HHS/United States T32 GM007863/GM/NIGMS NIH HHS/United States P30-CA04659234/Center for Cancer Research (CCR) R01 CA181654/CA/NCI NIH HHS/United States F31 CA271463/CA/NCI NIH HHS/United States

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