换一批
换一批TET2 regulates early and late transitions in exhausted CD8<sup>+</sup> T cell differentiation and limits CAR T cell function.
作者：
Alexander J,Dimitri [1]
;
Amy E,Baxter [2]
;
Gregory M,Chen [1]
;
Caitlin R,Hopkins [1]
;
Geoffrey T,Rouin [3]
;
Hua,Huang [2]
;
Weimin,Kong [1]
;
Christopher H,Holliday [4]
;
Volker,Wiebking [5]
;
Robert,Bartoszek [1]
;
Sydney,Drury [6]
;
Katherine,Dalton [6]
;
Owen M,Koucky [1]
;
Zeyu,Chen [2]
;
Josephine R,Giles [7]
;
Alexander T,Dils [8]
;
In-Young,Jung [1]
;
Roddy,O'Connor [9]
;
Sierra,Collins [10]
;
John K,Everett [11]
;
Kevin,Amses [11]
;
Scott,Sherrill-Mix [12]
;
Aditi,Chandra [13]
;
Naomi,Goldman [13]
;
Golnaz,Vahedi [13]
;
Julie K,Jadlowsky [14]
;
Regina M,Young [15]
;
Jan Joseph,Melenhorst [16]
;
Shannon L,Maude [3]
;
Bruce L,Levine [17]
;
Noelle V,Frey [18]
;
Shelley L,Berger [10]
;
Stephan A,Grupp [19]
;
David L,Porter [20]
;
Friederike,Herbst [15]
;
Matthew H,Porteus [5]
;
Shannon A,Carty [8]
;
Frederic D,Bushman [11]
;
Evan W,Weber [21]
;
E John,Wherry [7]
;
Martha S,Jordan [22]
;
Joseph A,Fraietta [1]
作者单位：
Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.;Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.;Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.;Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
[1]
Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.;Department for Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
[2]
Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.;Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
[3]
Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
[4]
Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics,, Stanford University, Palo Alto, CA 94304, USA.
[5]
Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.;Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
[6]
Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.;Department for Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.;Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, PA 19104, USA.
[7]
Division of Hematology-Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
[8]
Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.;Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.;Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.;Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, PA 19104, USA.
[9]
Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, PA 19104, USA.;Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.;Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
[10]
Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
[11]
Department of Microbiology, Genetics and Immunology, Michigan State University, East Lansing, MI 48824, USA.
[12]
Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.;Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.;Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
[13]
Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
[14]
Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.;Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
[15]
Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.;Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.;Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.;Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.;Cleveland Clinic Lerner College of Medicine, Cleveland, OH 44195, USA.
[16]
Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.;Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.;Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
[17]
Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.;Cleveland Clinic Lerner College of Medicine, Cleveland, OH 44195, USA.
[18]
Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
[19]
Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.;Division of Hematology and Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
[20]
Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.;Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.;Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.;Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.;Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, PA 19104, USA.
[21]
Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.;Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.;Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, PA 19104, USA.
[22]
主题词
细胞分化(Cell Differentiation);动物(Animals);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);小鼠(Mice);原癌基因蛋白质类(Proto-Oncogene Proteins);双加氧酶类(Dioxygenases);DNA结合蛋白质类(DNA-Binding Proteins);人类(Humans);淋巴细胞性脉络丛脑膜炎病毒(Lymphocytic choriomeningitis virus);淋巴细胞性脉络丛脑膜炎(Lymphocytic Choriomeningitis);免疫疗法, 过继(Immunotherapy, Adoptive)
DOI
10.1126/sciadv.adp9371
PMID
39536093
发布时间
2025-02-13
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Science advances
Science advances
2024年10卷46期
eadp9371页
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