"Aging" in co-amorphous systems: Dissolution decrease and non-negligible dissolution increase during storage without recrystallization.

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第一作者： Luyan,Shen

第一单位： Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang, China; Wenzhou Institute, University of Chinese Academy of Science, Wenzhou 325024, Zhejiang, China.

作者： Luyan,Shen ^[1] ; Xianzhi,Liu ^[1] ; Wencheng,Wu ^[1] ; Lin,Zhou ^[1] ; Guang,Liang ^[1] ; Yi,Wang ^[2] ; Wenqi,Wu ^[3]

作者单位： Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang, China; Wenzhou Institute, University of Chinese Academy of Science, Wenzhou 325024, Zhejiang, China. ^[1] Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang, China. ^[2] Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang, China; Wenzhou Institute, University of Chinese Academy of Science, Wenzhou 325024, Zhejiang, China. Electronic address: wenqiwu106@hotmail.com. ^[3]

关键词 Aging Co-amorphous systems Intrinsic dissolution rate (IDR)Physical stability Poorly water-soluble drugs