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Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ.

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第一作者: Christos,Kiourtis
第一单位: Cancer Research UK Scotland Institute, Garscube Estate, Glasgow, UK.;School of Cancer Sciences, University of Glasgow, Glasgow, UK.
作者单位: Cancer Research UK Scotland Institute, Garscube Estate, Glasgow, UK.;School of Cancer Sciences, University of Glasgow, Glasgow, UK. [1] Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK. [2] Cancer Research UK Scotland Institute, Garscube Estate, Glasgow, UK. [3] MRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.;Kidney Health Service, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia. [4] MRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK. [5] Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin, Berlin, Germany. [6] Liver Failure Group, Institute for Liver and Digestive Health, Division of Medicine, University College London, London, UK. [7] School of Cancer Sciences, University of Glasgow, Glasgow, UK. [8] Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.;Fibrofind ltd, William Leech Building, Medical School, Newcastle University, Newcastle upon Tyne, UK. [9] Medical Toxicology Centre, Edwardson Building, Newcastle University, Health Innovation Neighbourhood, Newcastle upon Tyne, UK. [10] Bioscience, Early Oncology, AstraZeneca, Cambridge, UK. [11] Department of Cellular Pathology, Royal Free London NHS Foundation Trust, London, UK.;UCL Cancer Institute, London, UK. [12] Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK. [13] Cancer Research UK Scotland Institute, Garscube Estate, Glasgow, UK.;School of Cancer Sciences, University of Glasgow, Glasgow, UK.;Department of Hematology, Mayo Clinic, Rochester, MN, USA.;Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.;Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA. [14] Liver Failure Group, Institute for Liver and Digestive Health, Division of Medicine, University College London, London, UK.;European Foundation for the Study of Chronic Liver Failure, Barcelona, Spain. [15] Cancer Research UK Scotland Institute, Garscube Estate, Glasgow, UK. t.bird@crukscotlandinstitute.ac.uk.;School of Cancer Sciences, University of Glasgow, Glasgow, UK. t.bird@crukscotlandinstitute.ac.uk.;MRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK. t.bird@crukscotlandinstitute.ac.uk. [16]
DOI 10.1038/s41556-024-01543-3
PMID 39537753
发布时间 2025-01-22
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