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Palmitoylation of TIM-3 promotes immune exhaustion and restrains antitumor immunity.

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第一作者： Zhaoying,Zhang

第一单位： Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo Medical College, Shandong University, 250012 Jinan, Shandong, China.

作者： Zhaoying,Zhang ^[1] ; Caiyue,Ren ^[1] ; Rong,Xiao ^[1] ; Shuaiya,Ma ^[1] ; Huimin,Liu ^[1] ; Yutong,Dou ^[1] ; Yuchen,Fan ^[2] ; Shuo,Wang ^[3] ; Peng,Zhan ^[3] ; Chengjiang,Gao ^[1] ; Xuetian,Yue ^[4] ; Chunyang,Li ^[5] ; Lifen,Gao ^[1] ; Xiaohong,Liang ^[1] ; Zhuanchang,Wu ^[1] ; Chunhong,Ma ^[6]

作者单位： Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo Medical College, Shandong University, 250012 Jinan, Shandong, China. ^[1] Department of Hepatology, Qilu Hospital, Cheeloo Medical College, Shandong University, 250012 Jinan, Shandong, China. ^[2] Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, 250012 Jinan, Shandong, China. ^[3] Department of Cellular Biology, School of Basic Medical Sciences, Shandong University, 250012 Jinan, China. ^[4] Key Laboratory for Experimental Teratology of the Ministry of Education, Department of Histology and Embryology, School of Basic Medical Sciences, Shandong University, 250012 Jinan, China. ^[5] Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo Medical College, Shandong University, 250012 Jinan, Shandong, China.;School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, 250012 Jinan, Shandong, China. ^[6]

医学主题词人类(Humans);动物(Animals);脂化作用(Lipoylation);小鼠(Mice);酰基转移酶类(Acyltransferases);杀伤细胞, 天然(Killer Cells, Natural);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);肝肿瘤(Liver Neoplasms);癌, 肝细胞(Carcinoma, Hepatocellular);细胞系, 肿瘤(Cell Line, Tumor);HEK293细胞(HEK293 Cells)

DOI 10.1126/sciimmunol.adp7302

PMID 39546589

发布时间 2025-07-01

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