首页> Journal of proteome research> A Shotgun Proteomic-Based Approach with a Q-Exactive Hybrid Quadrupole-Orbitrap High-Resolution Mass Spectrometer for the Assessment of Pesticide Mixture-Induced Neurotoxicity on a 3D-Developed Neurospheroid Model from Human Brain Meningiomas: Identification of Trityl-Post-Translational Modification.

A Shotgun Proteomic-Based Approach with a Q-Exactive Hybrid Quadrupole-Orbitrap High-Resolution Mass Spectrometer for the Assessment of Pesticide Mixture-Induced Neurotoxicity on a 3D-Developed Neurospheroid Model from Human Brain Meningiomas: Identification of Trityl-Post-Translational Modification.

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第一作者： Kaouthar,Louati

第一单位： Laboratory of Chemical, Galenic and Pharmacological Drug Development- LR12ES09, University of Monastir, Road Avicenne , 5000Monastir, Tunisia.

作者： Kaouthar,Louati ^[1] ; Amina,Maalej ^[2] ; Fatma,Kolsi ^[3] ; Rim,Kallel ^[4] ; Yassine,Gdoura ^[3] ; Mahdi,Borni ^[3] ; Leila Sellami,Hakim ^[5] ; Rania,Zribi ^[6] ; Sirine,Choura ^[2] ; Sami,Sayadi ^[7] ; Mohamed,Chamkha ^[2] ; Basma,Mnif ^[8] ; Zouheir,Khemakhem ^[9] ; Tahya Sellami,Boudawara ^[4] ; Mohamed Zaher,Boudawara ^[3] ; Abderrahman,Bouraoui ^[1] ; Jamil,Kraiem ^[1] ; Fathi,Safta ^[1]

作者单位： Laboratory of Chemical, Galenic and Pharmacological Drug Development- LR12ES09, University of Monastir, Road Avicenne , 5000Monastir, Tunisia. ^[1] Laboratory of Environmental Bioprocesses, Centre of Biotechnology of Sfax, Road of Sidi-Mansour, P.O. Box 1177 , 3018Sfax, Tunisia. ^[2] Department of Neurosurgery, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, 3089Sfax, Tunisia.;Faculty of Medicine, University of Sfax, Avenue of Majida Boulila, 3029Sfax, Tunisia. ^[3] Laboratory of Pathological Anatomy and Cytology, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, 3089 Sfax, Tunisia.;Faculty of Medicine, University of Sfax, Avenue of Majida Boulila, 3029Sfax, Tunisia. ^[4] Laboratory of Pathological Anatomy and Cytology, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, 3089 Sfax, Tunisia. ^[5] Faculty of Letters and Humanities, University of Sfax, Airport Road, Km 4.5, 3023 Sfax, Tunisia. ^[6] Biotechnology Program, Center for Sustainable Development, College of Arts and Sciences, Qatar University, 2713 Doha, Qatar. ^[7] Department of Bacteriology, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, 3089Sfax, Tunisia.;Faculty of Medicine, University of Sfax, Avenue of Majida Boulila, 3029Sfax, Tunisia. ^[8] Legal Medicine Department, Habib Bourguiba University Hospital, Road El Ain km 1.5, Avenue of Ferdaous, 3089 Sfax, Tunisia.;Faculty of Medicine, University of Sfax, Avenue of Majida Boulila, 3029Sfax, Tunisia. ^[9]

关键词 3D neurospheroids model brain tumors neurotoxicity oxidative stress pesticides post-translational modification proteomics tandem mass spectrometry toxicity biomarkers