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MOSES: a methylation-based gene association approach for unveiling environmentally regulated genes linked to a trait or disease.

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第一作者： Soyeon,Kim

第一单位： Division of Pulmonary Medicine, Department of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

作者： Soyeon,Kim ^[1] ; Yidi,Qin ^[2] ; Hyun Jung,Park ^[2] ; Rebecca I Caldino,Bohn ^[2] ; Molin,Yue ^[3] ; Zhongli,Xu ^[4] ; Erick,Forno ^[1] ; Wei,Chen ^[1] ; Juan C,Celedón ^[5]

作者单位： Division of Pulmonary Medicine, Department of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. ^[1] Department of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. ^[2] Department of Biostatistics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. ^[3] School of Medicine, Tsinghua University, Beijing, China. ^[4] Division of Pulmonary Medicine, Department of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. juan.celedon@chp.edu. ^[5]

关键词 Asthma DNA methylation Gene expression prediction Gene-level association tests MOSES (methylation-based gene association method)Machine learning Nasal epithelium PrediXcan TWAS (transcriptome-wide association studies)eQTM (expression quantitative trait methylation)